Literature DB >> 2832680

Antitumor activity of SRI 62-834, a cyclic ether analog of ET-18-OCH3.

W J Houlihan1, M L Lee, P G Munder, G M Nemecek, D A Handley, C M Winslow, J Happy, C Jaeggi.   

Abstract

SRI 62-834, an analog of the antitumor agent ET-18-OCH3 in which the oxygen atom at carbon atom 2 has been incorporated into a five-membered heterocycle, has been prepared and evaluated as an antitumor agent. The compound exhibited good cytotoxicity in vitro against a variety of tumor cell lines and was as effective as ET-18-OCH3 given orally in the mouse Meth A sarcoma model. SRI 62-834 was shown to be an inhibitor of platelet-derived growth factor (PDGF), possibly at the receptor level, and platelet-activating factor (PAF) at the receptor level.

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Year:  1987        PMID： 2832680     DOI： 10.1007/BF02535549

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  32 in total

1.  Cell propagation on films of polymeric fluorocarbon as a means to regulate pericellular pH and pO(2) in cultured monolayers.

Authors:  P G. Munder; M Modolell; D F. Hoelzl Wallach
Journal:  FEBS Lett       Date:  1971-06-24       Impact factor: 4.124

2.  Purification of the platelet-derived growth factor receptor by using an anti-phosphotyrosine antibody.

Authors:  T O Daniel; P M Tremble; A R Frackelton; L T Williams
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

3.  The biocleavage of alkyl glyceryl ethers in Morris hepatomas and other transplantable neoplasms.

Authors:  J F Soodsma; C Piantadosi; F Snyder
Journal:  Cancer Res       Date:  1970-02       Impact factor: 12.701

4.  Detection of c-sis transcripts and synthesis of PDGF-like proteins by human osteosarcoma cells.

Authors:  D T Graves; A J Owen; R K Barth; P Tempst; A Winoto; L Fors; L E Hood; H N Antoniades
Journal:  Science       Date:  1984-11-23       Impact factor: 47.728

Review 5.  Anti-tumor action of alkyl-lysophospholipids (Review).

Authors:  W E Berdel; W R Bausert; U Fink; J Rastetter; P G Munder
Journal:  Anticancer Res       Date:  1981       Impact factor: 2.480

6.  Purging murine leukemic marrow with alkyl-lysophospholipids.

Authors:  L Glasser; L B Somberg; W R Vogler
Journal:  Blood       Date:  1984-12       Impact factor: 22.113

7.  Cytotoxicity of alkyl-lysophospholipid derivatives and low-alkyl-cleavage enzyme activities in rat brain tumor cells.

Authors:  W E Berdel; E Greiner; U Fink; D Stavrou; A Reichert; J Rastetter; D R Hoffman; F Snyder
Journal:  Cancer Res       Date:  1983-02       Impact factor: 12.701

8.  Evidence that a human osteosarcoma cell line which secretes a mitogen similar to platelet-derived growth factor requires growth factors present in platelet-poor plasma.

Authors:  D T Graves; A J Owen; H N Antoniades
Journal:  Cancer Res       Date:  1983-01       Impact factor: 12.701

9.  Synthesis of a PDGF-like growth factor in human glioma and sarcoma cells suggests the expression of the cellular homologue to the transforming protein of simian sarcoma virus.

Authors:  C Betsholtz; C H Heldin; M Nister; B Ek; A Wasteson; B Westermark
Journal:  Biochem Biophys Res Commun       Date:  1983-11-30       Impact factor: 3.575

10.  Induction of differentiation of cultured human and mouse myeloid leukemia cells by alkyl-lysophospholipids.

Authors:  Y Honma; T Kasukabe; M Hozumi; S Tsushima; H Nomura
Journal:  Cancer Res       Date:  1981-08       Impact factor: 12.701
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  6 in total

1.  Effects of hexadecylphosphocholine on protein kinase C and TPA-induced differentiation of HL60 cells.

Authors:  M Shoji; R L Raynor; E A Fleer; H Eibl; W R Vogler; J F Kuo
Journal:  Lipids       Date:  1991-02       Impact factor: 1.880

Review 2.  Biosynthesis and biotransformation of ether lipids.

Authors:  H K Mangold; N Weber
Journal:  Lipids       Date:  1987-11       Impact factor: 1.880

3.  Stimulation of tumour necrosis factor release by cytotoxic analogues of platelet-activating factor.

Authors:  F H Valone; N M Ruis
Journal:  Immunology       Date:  1992-05       Impact factor: 7.397

4.  Testing the hypothesis that amphiphilic antineoplastic lipid analogues act through reduction of membrane curvature elastic stress.

Authors:  Marcus Dymond; George Attard; Anthony D Postle
Journal:  J R Soc Interface       Date:  2008-11-06       Impact factor: 4.118

5.  Is metabolism an important arbiter of anticancer activity of ether lipids? Metabolism of SRI 62-834 and hexadecylphosphocholine by [31P]-NMR spectroscopy and comparison of their cytotoxicities with those of their metabolites.

Authors:  F E Bishop; C Dive; S Freeman; A Gescher
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

6.  Growth arrest vs direct cytotoxicity and the importance of molecular structure for the in vitro anti-tumour activity of ether lipids.

Authors:  M Lohmeyer; P Workman
Journal:  Br J Cancer       Date:  1995-08       Impact factor: 7.640
  6 in total

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