Dario Genovesi1, Giuseppe Vergaro2, Michele Emdin2, Assuero Giorgetti3, Paolo Marzullo3. 1. Nuclear Medicine Unit - Fondazione CNR/Regione Toscana "G. Monasterio", Via Moruzzi 1, 56124, Pisa, Italy. dario.genovesi@ftgm.it. 2. Cardiovascular Medicine Unit - Fondazione CNR/Regione Toscana "G. Monasterio", Pisa, Italy. 3. Nuclear Medicine Unit - Fondazione CNR/Regione Toscana "G. Monasterio", Via Moruzzi 1, 56124, Pisa, Italy.
Abstract
BACKGROUND: One of the most frequent disorders which lead to cardiac amyloidosis is transthyretin-related amyloidosis (ATTR). Some PET radio-pharmaceuticals for the detection of beta-amyloid deposits within the brain have shown to be able to detect also cardiac amyloid deposits. We present a case of a man with ATTR studied with [18F]-florbetaben PET-CT. RESULTS: Total-body scan showed a moderate uptake in the bone marrow, especially in correspondence of the vertebral column, while no significant myocardial uptake was present. Cardiac-focused scans showed low mean cardiac SUV values confirming the absence of significant myocardial uptake. Brain scan showed a significant cortical brain uptake of the radio-pharmaceutical more evident in correspondence of frontal and temporal lobes. CONCLUSIONS: Distinct subtypes of amyloidosis show different uptake of the radiotracer. Brain amyloid deposition in the presence of a systemic disease could not be caused by the same amyloid precursor.
BACKGROUND: One of the most frequent disorders which lead to cardiac amyloidosis is transthyretin-related amyloidosis (ATTR). Some PET radio-pharmaceuticals for the detection of beta-amyloid deposits within the brain have shown to be able to detect also cardiac amyloid deposits. We present a case of a man with ATTR studied with [18F]-florbetaben PET-CT. RESULTS: Total-body scan showed a moderate uptake in the bone marrow, especially in correspondence of the vertebral column, while no significant myocardial uptake was present. Cardiac-focused scans showed low mean cardiac SUV values confirming the absence of significant myocardial uptake. Brain scan showed a significant cortical brain uptake of the radio-pharmaceutical more evident in correspondence of frontal and temporal lobes. CONCLUSIONS: Distinct subtypes of amyloidosis show different uptake of the radiotracer. Brain amyloid deposition in the presence of a systemic disease could not be caused by the same amyloid precursor.
Authors: Sharmila Dorbala; Divya Vangala; James Semer; Christopher Strader; John R Bruyere; Marcelo F Di Carli; Stephen C Moore; Rodney H Falk Journal: Eur J Nucl Med Mol Imaging Date: 2014-05-20 Impact factor: 9.236
Authors: Jean D Sipe; Merrill D Benson; Joel N Buxbaum; Shu-Ichi Ikeda; Giampaolo Merlini; Maria J M Saraiva; Per Westermark Journal: Amyloid Date: 2016-11-24 Impact factor: 7.141
Authors: Mi-Ae Park; Robert F Padera; Anthony Belanger; Shipra Dubey; David H Hwang; Vikas Veeranna; Rodney H Falk; Marcelo F Di Carli; Sharmila Dorbala Journal: Circ Cardiovasc Imaging Date: 2015-08 Impact factor: 7.792
Authors: Fara Petruzziello; Pio Zeppa; Lucio Catalano; Immacolata Cozzolino; Giuseppe Gargiulo; Pellegrino Musto; Fiorella D'Auria; Vincenzo Liso; Rita Rizzi; Nadia Caruso; Catello Califano; Eugenio Piro; Maurizio Musso; Vincenza Bonanno; Antonietta Pia Falcone; Salvatore Tafuto; Francesco Di Raimondo; Michelino De Laurentiis; Fabrizio Pane; Lucio Palombini; Bruno Rotoli Journal: Ann Hematol Date: 2009-11-06 Impact factor: 3.673
Authors: Julian D Gillmore; Mathew S Maurer; Rodney H Falk; Giampaolo Merlini; Thibaud Damy; Angela Dispenzieri; Ashutosh D Wechalekar; John L Berk; Candida C Quarta; Martha Grogan; Helen J Lachmann; Sabahat Bokhari; Adam Castano; Sharmila Dorbala; Geoff B Johnson; Andor W J M Glaudemans; Tamer Rezk; Marianna Fontana; Giovanni Palladini; Paolo Milani; Pierluigi L Guidalotti; Katarina Flatman; Thirusha Lane; Frederick W Vonberg; Carol J Whelan; James C Moon; Frederick L Ruberg; Edward J Miller; David F Hutt; Bouke P Hazenberg; Claudio Rapezzi; Philip N Hawkins Journal: Circulation Date: 2016-04-22 Impact factor: 29.690
Authors: M F Santarelli; D Genovesi; M Scipioni; V Positano; B Favilli; A Giorgetti; G Vergaro; L Landini; M Emdin; P Marzullo Journal: J Nucl Cardiol Date: 2021-04-16 Impact factor: 3.872
Authors: T Wagner; J Page; M Burniston; A Skillen; J C Ross; R Manwani; D McCool; P N Hawkins; Ashutosh D Wechalekar Journal: Eur J Nucl Med Mol Imaging Date: 2018-04-12 Impact factor: 9.236