| Literature DB >> 28325147 |
Daipeng Xiao1, Zhenbao Liu2, Shanshan Zhang1, Mi Zhou3, Fen He1, Ming Zou3, Junying Peng3, Xiong Xie1, Yanfei Liu1, Dongming Peng3.
Abstract
Berberine, a quaternary ammonium protoberberine alkaloid with an isoquinoline scaffold isolated from medicinal herbs, exhibits a wide spectrum of pharmacological activities. Berberine has been used in traditional Chinese medicine and Ayurvedic medicine. However, it has poor bioavailability, which seriously limits its application and development. The chemical transformation of natural products is an effective method to improve pharmacological activities. Researches have been carried out on the modification of berberine to obtain better pharmacological properties. In this paper, the structural modifications of berberine for different biological activities and its underlying mechanisms are reviewed. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.Entities:
Keywords: Berberine; bioavailability; chemical transformation; mechanisms; pharmacological activities; structural modification.
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Year: 2018 PMID： 28325147 DOI： 10.2174/1389557517666170321103139
Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862