Literature DB >> 2832509

The human interleukin 2 receptor beta chain (p70). Direct identification, partial purification, and patterns of expression on peripheral blood mononuclear cells.

M Sharon1, J P Siegel, G Tosato, J Yodoi, T L Gerrard, W J Leonard.   

Abstract

IL-2 binds to high- and low-affinity receptors on activated T cells. The high-affinity receptor was hypothesized to consist of the noncovalent association between the alpha chain (IL-2-R-alpha, p55) and a beta chain (IL-2-R-beta, p70), whereas the low-affinity receptor consists of p55 without p70. We now directly identify p70 as a 65-77-kD glycoprotein doublet. Preparative quantities of the IL-2/p70 complex have been isolated. Further, we demonstrate that p70 is the principal IL-2 binding protein on both resting CD4+ and CD8+ T cells and that both p70 and p55 can be induced on normal B cells and monocytes.

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Year:  1988        PMID： 2832509      PMCID： PMC2188899          DOI： 10.1084/jem.167.3.1265

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  16 in total

1.  TCGF (IL 2)-receptor inducing factor(s). I. Regulation of IL 2 receptor on a natural killer-like cell line (YT cells).

Authors:  J Yodoi; K Teshigawara; T Nikaido; K Fukui; T Noma; T Honjo; M Takigawa; M Sasaki; N Minato; M Tsudo
Journal:  J Immunol       Date:  1985-03       Impact factor: 5.422

2.  Only high-affinity receptors for interleukin 2 mediate internalization of ligand.

Authors:  A M Weissman; J B Harford; P B Svetlik; W L Leonard; J M Depper; T A Waldmann; W C Greene; R D Klausner
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205

3.  Identification of the components of the murine T cell antigen receptor complex.

Authors:  L E Samelson; J B Harford; R D Klausner
Journal:  Cell       Date:  1985-11       Impact factor: 41.582

4.  Effects of natural and recombinant IL 2 on regulation of IFN gamma production and natural killer activity: lack of involvement of the Tac antigen for these immunoregulatory effects.

Authors:  J R Ortaldo; A T Mason; J P Gerard; L E Henderson; W Farrar; R F Hopkins; R B Herberman; H Rabin
Journal:  J Immunol       Date:  1984-08       Impact factor: 5.422

5.  A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor.

Authors:  W J Leonard; J M Depper; T Uchiyama; K A Smith; T A Waldmann; W C Greene
Journal:  Nature       Date:  1982-11-18       Impact factor: 49.962

6.  The murine interleukin 2 receptor. Irreversible cross-linking of radiolabeled interleukin 2 to high affinity interleukin 2 receptors reveals a noncovalently associated subunit.

Authors:  H Saragovi; T R Malek
Journal:  J Immunol       Date:  1987-09-15       Impact factor: 5.422

7.  Characterization of the human receptor for T-cell growth factor.

Authors:  W J Leonard; J M Depper; R J Robb; T A Waldmann; W C Greene
Journal:  Proc Natl Acad Sci U S A       Date:  1983-11       Impact factor: 11.205

8.  Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen.

Authors:  R J Robb; W C Greene; C M Rusk
Journal:  J Exp Med       Date:  1984-10-01       Impact factor: 14.307

9.  Expression of interleukin 2 receptors and binding of interleukin 2 by gamma interferon-induced human leukemic and normal monocytic cells.

Authors:  F Herrmann; S A Cannistra; H Levine; J D Griffin
Journal:  J Exp Med       Date:  1985-09-01       Impact factor: 14.307

10.  Expression of interleukin 2 receptors on activated human B cells.

Authors:  T A Waldmann; C K Goldman; R J Robb; J M Depper; W J Leonard; S O Sharrow; K F Bongiovanni; S J Korsmeyer; W C Greene
Journal:  J Exp Med       Date:  1984-11-01       Impact factor: 14.307
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  25 in total

1.  Bcl-3 expression promotes cell survival following interleukin-4 deprivation and is controlled by AP1 and AP1-like transcription factors.

Authors:  A Rebollo; L Dumoutier; J C Renauld; A Zaballos; V Ayllón; C Martínez-A
Journal:  Mol Cell Biol       Date:  2000-05       Impact factor: 4.272

Review 2.  The clinical immunobiology of interleukin-2: potential modified uses for improved cancer treatment.

Authors:  S D Voss; G Weil-Hillman; J A Hank; J A Sosman; P M Sondel
Journal:  Bull N Y Acad Med       Date:  1989-01

3.  Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies.

Authors:  M Tsudo; F Kitamura; M Miyasaka
Journal:  Proc Natl Acad Sci U S A       Date:  1989-03       Impact factor: 11.205

4.  The monocyte interleukin-2 receptor light chain: production of cell-associated and soluble interleukin-2 receptor by monocytes.

Authors:  E M Kniep; I Strelow; M L Lohmann-Matthes
Journal:  Immunology       Date:  1992-02       Impact factor: 7.397

5.  Expression of IL-2 receptor p55 and p75 chains by human B lymphocytes: effects of activation and differentiation.

Authors:  H Zola; H Weedon; G R Thompson; M C Fung; E Ingley; A J Hapel
Journal:  Immunology       Date:  1991-02       Impact factor: 7.397

6.  Identification of a direct interaction between interleukin 2 and the p64 interleukin 2 receptor gamma chain.

Authors:  S D Voss; T P Leary; P M Sondel; R J Robb
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-15       Impact factor: 11.205

7.  A 100-kilodalton protein is associated with the murine interleukin 2 receptor: biochemical evidence that p100 is distinct from the alpha and beta chains.

Authors:  M Sharon; J R Gnarra; W J Leonard
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

8.  Preferential expression of IL-2 receptor subunits on memory populations within CD4+ and CD8+ T cells.

Authors:  K Taga; Y Kasahara; A Yachie; T Miyawaki; N Taniguchi
Journal:  Immunology       Date:  1991-01       Impact factor: 7.397

9.  Human interleukin 2 receptor beta-chain gene: chromosomal localization and identification of 5' regulatory sequences.

Authors:  J R Gnarra; H Otani; M G Wang; O W McBride; M Sharon; W J Leonard
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

10.  Human immunodeficiency virus-infected adherent cell-derived inhibitory factor (p29) inhibits normal T cell proliferation through decreased expression of high affinity interleukin-2 receptors and production of interleukin-2.

Authors:  A Ammar; Y Sahraoui; A Tsapis; A M Bertoli; C Jasmin; V Georgoulias
Journal:  J Clin Invest       Date:  1992-07       Impact factor: 14.808
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