Literature DB >> 28324490

Assessment of Mitophagy in iPS Cell-Derived Neurons.

Kei-Ichi Ishikawa1, Akihiro Yamaguchi2, Hideyuki Okano3, Wado Akamatsu4.   

Abstract

Aberrant mitochondrial function is associated with many neurological diseases. Mitophagy is a key mechanism for the elimination of damaged mitochondria and maintenance of mitochondrial homeostasis. Induced pluripotent stem (iPS) cell technologies developed over the last decade have allowed us to analyze functions of the human neuron. Here we describe an efficient induction method from human iPS cells to neurons, followed by an image-based mitophagy assay.

Entities:  

Keywords:  Autophagy; Mitophagy; Neurons; Parkinson’s disease; iPS cells

Mesh：

Year:  2018        PMID： 28324490     DOI： 10.1007/7651_2017_10

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  2 in total

1.  Differentiation of Midbrain Dopaminergic Neurons from Human iPS Cells.

Authors:  Kei-Ichi Ishikawa; Risa Nonaka; Wado Akamatsu
Journal:  Methods Mol Biol       Date:  2021

2.  iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates.

Authors:  A H Laperle; S Sances; N Yucer; V J Dardov; V J Garcia; R Ho; A N Fulton; M R Jones; K M Roxas; P Avalos; D West; M G Banuelos; Z Shu; R Murali; N T Maidment; J E Van Eyk; M Tagliati; C N Svendsen
Journal:  Nat Med       Date:  2020-01-27       Impact factor: 53.440
  2 in total

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