Literature DB >> 28322967

Regulating dyslipidemia effect of polysaccharides from Pleurotus ostreatus on fat-emulsion-induced hyperlipidemia rats.

Yan Zhang1, Zhuowei Wang2, Gang Jin3, Xiudong Yang3, Hongli Zhou3.   

Abstract

This study was conducted to evaluate the regulating dyslipidemia effect of polysaccharides from Pleurotus ostreatus (POP) on fat-emulsion-induced hyperlipidemia rats. A plasma metabonomics method based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was applied to analyze the holistic mechanism of POP in a hyperlipidemia rat model. Multivariate statistical approaches such as principal component analysis and orthogonal projection to latent structure square-discriminant analysis revealed distinctions among the control, hyperlipidemia model, and POP groups.The results demonstrated that POP had an effect on regulating dyslipidemia. The mechanism of POP on regulating dyslipidemia was partially relevant with correcting the abnormal levels of fifteen potential biomarkers towards their normal levels. These biomarkers were belong to glycerophospholipids, fatty acids, prenol lipids, sphingolipids metabolism.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Biomarkers; Hyperlipidemia; Metabonomics; Pleurotus ostreatus; Polysaccharides

Mesh：

Substances：

Year:  2017        PMID： 28322967     DOI： 10.1016/j.ijbiomac.2017.03.084

Source DB:  PubMed          Journal:  Int J Biol Macromol        ISSN： 0141-8130            Impact factor:   6.953


  10 in total

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  10 in total

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