Klaas Heinemann1, Clare Barnett2, Suzanne Reed2, Sabine Möhner2, Thai Do Minh2. 1. ZEG - Berlin Center for Epidemiology and Health Research, Berlin, Germany. Electronic address: k.heinemann@zeg-berlin.de. 2. ZEG - Berlin Center for Epidemiology and Health Research, Berlin, Germany.
Abstract
OBJECTIVE: The objective of the study was to determine if delivery and lactation are risk factors for complete intrauterine device perforations. STUDY DESIGN: We performed a reanalysis of the European Active Surveillance Study on Intra-Uterine Devices data set using complete penetration of the myometrium as the definition for perforation. RESULTS: Of the 61,448 women enrolled (70% levonorgestrel, 30% copper devices), we identified 58 complete perforations, 30 of which occurred in lactating women. Incidence per 1000 insertions was 4.5 (95% confidence interval [CI]: 3.0-6.4) for lactating and 0.6 (95% CI: 0.4-0.9) for nonlactating women. Time since delivery was also associated with perforation risk. CONCLUSIONS: Lactation and delivery are independent cofactors for perforation. Results do not differ when restricting the definition of perforation.
OBJECTIVE: The objective of the study was to determine if delivery and lactation are risk factors for complete intrauterine device perforations. STUDY DESIGN: We performed a reanalysis of the European Active Surveillance Study on Intra-Uterine Devices data set using complete penetration of the myometrium as the definition for perforation. RESULTS: Of the 61,448 women enrolled (70% levonorgestrel, 30% copper devices), we identified 58 complete perforations, 30 of which occurred in lactating women. Incidence per 1000 insertions was 4.5 (95% confidence interval [CI]: 3.0-6.4) for lactating and 0.6 (95% CI: 0.4-0.9) for nonlactating women. Time since delivery was also associated with perforation risk. CONCLUSIONS:Lactation and delivery are independent cofactors for perforation. Results do not differ when restricting the definition of perforation.
Authors: Mary S Anthony; Mary Anne Armstrong; Darios Getahun; Delia Scholes; Jennifer Gatz; Renate Schulze-Rath; Debbie Postlethwaite; Maqdooda Merchant; Amy L Alabaster; Giulia Chillemi; Tina Raine-Bennett; Fagen Xie; Vicki Y Chiu; Theresa M Im; Harpreet S Takhar; Michael Fassett; Jane Grafton; David Cronkite; Laura Ichikawa; Susan D Reed; Siu Lui Hui; Mary E Ritchey; Catherine W Saltus; Elizabeth B Andrews; Kenneth J Rothman; Alex Asiimwe; Richard Lynen; Juliane Schoendorf Journal: Clin Epidemiol Date: 2019-07-23 Impact factor: 4.790