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Literature DB >> 28322585

Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes.

Karen M Doody¹, Nunzio Bottini², Gary S Firestein².

Abstract

Rheumatoid arthritis is an immune-mediated disease that primarily affects diarthrodial joints. Susceptibility and severity of this disease are influenced by nongenetic factors, such as environmental stress, suggesting an important role of epigenetic changes. In this review, we summarize the epigenetic changes (DNA methylation, histone modification and miRNA expression) in fibroblast-like synoviocytes, which are the joint-lining mesenchymal cells that play an important role in joint inflammation and damage. We also review the effects of these epigenetic changes on rheumatoid arthritis pathogenesis and discuss their therapeutic potential.

Entities: Disease

Keywords: epigenetics; fibroblast-like synoviocytes; histone; methylation; microRNA; rheumatoid arthritis

Mesh：

Substances：
MicroRNAs

Year: 2017 PMID： 28322585 PMCID： PMC5549652 DOI： 10.2217/epi-2016-0151

Source DB: PubMed Journal: Epigenomics ISSN： 1750-192X Impact factor: 4.778

96 in total

1. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α.

Authors: Shu Zhu; Wen Pan; Xinyang Song; Yan Liu; Xinrui Shao; Yuanjia Tang; Dong Liang; Dongyi He; Honglin Wang; Wenjun Liu; Yufang Shi; John B Harley; Nan Shen; Youcun Qian
Journal: Nat Med Date: 2012-07 Impact factor: 53.440

Review 2. DNA methylation and human disease.

Authors: Keith D Robertson
Journal: Nat Rev Genet Date: 2005-08 Impact factor: 53.242

Review 3. Targeting bromodomains: epigenetic readers of lysine acetylation.

Authors: Panagis Filippakopoulos; Stefan Knapp
Journal: Nat Rev Drug Discov Date: 2014-04-22 Impact factor: 84.694

Review 4. Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.

Authors: Katrina J Falkenberg; Ricky W Johnstone
Journal: Nat Rev Drug Discov Date: 2014-08-18 Impact factor: 84.694

Review 5. Deregulation and therapeutic potential of microRNAs in arthritic diseases.

Authors: Rita Vicente; Danièle Noël; Yves-Marie Pers; Florence Apparailly; Christian Jorgensen
Journal: Nat Rev Rheumatol Date: 2015-12-24 Impact factor: 20.543

6. Increased recycling of polyamines is associated with global DNA hypomethylation in rheumatoid arthritis synovial fibroblasts.

Authors: Emmanuel Karouzakis; Renate E Gay; Steffen Gay; Michel Neidhart
Journal: Arthritis Rheum Date: 2011-12-14

7. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints.

Authors: Stephanie Lefèvre; Anette Knedla; Christoph Tennie; Andreas Kampmann; Christina Wunrau; Robert Dinser; Adelheid Korb; Eva-Maria Schnäker; Ingo H Tarner; Paul D Robbins; Christopher H Evans; Henning Stürz; Jürgen Steinmeyer; Steffen Gay; Jürgen Schölmerich; Thomas Pap; Ulf Müller-Ladner; Elena Neumann
Journal: Nat Med Date: 2009-11-08 Impact factor: 53.440

Review 8. Uncovering the Role of the Methylome in Dementia and Neurodegeneration.

Authors: Hans-Ulrich Klein; Philip L De Jager
Journal: Trends Mol Med Date: 2016-07-13 Impact factor: 11.951

9. Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression.

Authors: Lorenzo de la Rica; José M Urquiza; David Gómez-Cabrero; Abul B M M K Islam; Nuria López-Bigas; Jesper Tegnér; René E M Toes; Esteban Ballestar
Journal: J Autoimmun Date: 2013-01-08 Impact factor: 7.094

10. Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay.

Authors: Aleksander M Grabiec; Olexandr Korchynskyi; Paul P Tak; Kris A Reedquist
Journal: Ann Rheum Dis Date: 2011-09-27 Impact factor: 19.103

24 in total

1. The P2X7 receptor (P2X7R)-specific antagonist A804598 inhibits inflammatory reaction in human fibroblast-like synoviocytes.

Authors: Yu Liu; Yongwei Wu; Sanjun Gu; Qudong Yin; Haifeng Li; Jian Wang; Dechun Geng; Yaozeng Xu
Journal: Am J Transl Res Date: 2020-01-15 Impact factor: 4.060

2. Epigenetic Regulation of Nutrient Transporters in Rheumatoid Arthritis Fibroblast-like Synoviocytes.

Authors: Alyssa Torres; Brian Pedersen; Isidoro Cobo; Rizi Ai; Roxana Coras; Jessica Murillo-Saich; Gyrid Nygaard; Elsa Sanchez-Lopez; Anne Murphy; Wei Wang; Gary S Firestein; Monica Guma
Journal: Arthritis Rheumatol Date: 2022-06-02 Impact factor: 15.483

3. [Effects of Sidaxue, a Miao ethnomedicine recipe, on apoptosis and pyrolysis of human fibroblast-like synovial cells in rheumatoid arthritis].

Authors: N Wu; T Yuan; J Ji; Y Cheng; M Li; X Liang; J Sun; H Liu; C Wu
Journal: Nan Fang Yi Ke Da Xue Xue Bao Date: 2021-10-20

4. Cinnamaldehyde Attenuates the Progression of Rheumatoid Arthritis through Down-Regulation of PI3K/AKT Signaling Pathway.

Authors: Xiang Li; Yue Wang
Journal: Inflammation Date: 2020-10 Impact factor: 4.092

Review 9. Synovial fibroblasts in 2017.

Authors: Caroline Ospelt
Journal: RMD Open Date: 2017-10-15

Review 10. The Effects of MicroRNAs on Key Signalling Pathways and Epigenetic Modification in Fibroblast-Like Synoviocytes of Rheumatoid Arthritis.

Authors: Wenming Hong; Pengying Zhang; Xinming Wang; Jiajie Tu; Wei Wei
Journal: Mediators Inflamm Date: 2018-05-10 Impact factor: 4.711