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Literature DB >> 28322385

Dicarboxylic acids as pH sensors for hyperpolarized ¹³C magnetic resonance spectroscopic imaging.

D E Korenchan¹, C Taglang, C von Morze, J E Blecha, J W Gordon, R Sriram, P E Z Larson, D B Vigneron, H F VanBrocklin, J Kurhanewicz, D M Wilson, R R Flavell.

Abstract

Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-13C,D10]diethylmalonic acid, which exhibits a large pH-dependent 13C chemical shift over the physiological range. We demonstrate that co-polarization with [1-13C,D9]tert-butanol accurately measures pH via13C NMR and magnetic resonance spectroscopic imaging in phantoms.

Entities: Chemical Disease Species

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Year: 2017 PMID： 28322385 PMCID： PMC5462110 DOI： 10.1039/c7an00076f

Source DB: PubMed Journal: Analyst ISSN： 0003-2654 Impact factor: 4.616

22 in total

Review 1. Imaging pH with hyperpolarized 13C.

Authors: Ferdia A Gallagher; Mikko I Kettunen; Kevin M Brindle
Journal: NMR Biomed Date: 2011-08-03 Impact factor: 4.044

Review 2. Why do cancers have high aerobic glycolysis?

Authors: Robert A Gatenby; Robert J Gillies
Journal: Nat Rev Cancer Date: 2004-11 Impact factor: 60.716

Review 3. The relevance of tumour pH to the treatment of malignant disease.

Authors: J L Wike-Hooley; J Haveman; H S Reinhold
Journal: Radiother Oncol Date: 1984-12 Impact factor: 6.280

4. Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate.

Authors: Ferdia A Gallagher; Mikko I Kettunen; Sam E Day; De-En Hu; Jan Henrik Ardenkjaer-Larsen; René in 't Zandt; Pernille R Jensen; Magnus Karlsson; Klaes Golman; Mathilde H Lerche; Kevin M Brindle
Journal: Nature Date: 2008-05-28 Impact factor: 49.962

5. Caged [(18)F]FDG Glycosylamines for Imaging Acidic Tumor Microenvironments Using Positron Emission Tomography.

Authors: Robert R Flavell; Charles Truillet; Melanie K Regan; Tanushree Ganguly; Joseph E Blecha; John Kurhanewicz; Henry F VanBrocklin; Kayvan R Keshari; Christopher J Chang; Michael J Evans; David M Wilson
Journal: Bioconjug Chem Date: 2015-12-22 Impact factor: 4.774

6. Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate.

Authors: Sarah J Nelson; John Kurhanewicz; Daniel B Vigneron; Peder E Z Larson; Andrea L Harzstark; Marcus Ferrone; Mark van Criekinge; Jose W Chang; Robert Bok; Ilwoo Park; Galen Reed; Lucas Carvajal; Eric J Small; Pamela Munster; Vivian K Weinberg; Jan Henrik Ardenkjaer-Larsen; Albert P Chen; Ralph E Hurd; Liv-Ingrid Odegardstuen; Fraser J Robb; James Tropp; Jonathan A Murray
Journal: Sci Transl Med Date: 2013-08-14 Impact factor: 17.956

7. A novel technology for the imaging of acidic prostate tumors by positron emission tomography.

Authors: Amy L Vāvere; Gráinne B Biddlecombe; William M Spees; Joel R Garbow; Dayanjali Wijesinghe; Oleg A Andreev; Donald M Engelman; Yana K Reshetnyak; Jason S Lewis
Journal: Cancer Res Date: 2009-05-05 Impact factor: 12.701

8. Radioiodinated phenylalkyl malonic acid derivatives as pH-sensitive SPECT tracers.

Authors: Matthias Bauwens; Marijke De Saint-Hubert; Jan Cleynhens; Laura Brams; Ellen Devos; Felix M Mottaghy; Alfons Verbruggen
Journal: PLoS One Date: 2012-06-13 Impact factor: 3.240

9. Hyperpolarized 15N-pyridine derivatives as pH-sensitive MRI agents.

Authors: Weina Jiang; Lloyd Lumata; Wei Chen; Shanrong Zhang; Zoltan Kovacs; A Dean Sherry; Chalermchai Khemtong
Journal: Sci Rep Date: 2015-03-16 Impact factor: 4.379

10. ¹⁵N Hyperpolarization of Imidazole-¹⁵N₂ for Magnetic Resonance pH Sensing via SABRE-SHEATH.

Authors: Roman V Shchepin; Danila A Barskiy; Aaron M Coffey; Thomas Theis; Fan Shi; Warren S Warren; Boyd M Goodson; Eduard Y Chekmenev
Journal: ACS Sens Date: 2016-04-14 Impact factor: 7.711

6 in total

1. Hyperpolarized ⁸⁹Y-EDTMP complex as a chemical shift-based NMR sensor for pH at the physiological range.

Authors: Qing Wang; Christopher Parish; Peter Niedbalski; James Ratnakar; Zoltan Kovacs; Lloyd Lumata
Journal: J Magn Reson Date: 2020-09-29 Impact factor: 2.229

2. Late-stage deuteration of ¹³C-enriched substrates for T₁ prolongation in hyperpolarized ¹³C MRI.

Authors: Céline Taglang; David E Korenchan; Cornelius von Morze; Justin Yu; Chloé Najac; Sinan Wang; Joseph E Blecha; Sukumar Subramaniam; Robert Bok; Henry F VanBrocklin; Daniel B Vigneron; Sabrina M Ronen; Renuka Sriram; John Kurhanewicz; David M Wilson; Robert R Flavell
Journal: Chem Commun (Camb) Date: 2018-05-17 Impact factor: 6.222

3. Using bidirectional chemical exchange for improved hyperpolarized [¹³ C]bicarbonate pH imaging.

Authors: David E Korenchan; Jeremy W Gordon; Sukumar Subramaniam; Renuka Sriram; Celine Baligand; Mark VanCriekinge; Robert Bok; Daniel B Vigneron; David M Wilson; Peder E Z Larson; John Kurhanewicz; Robert R Flavell
Journal: Magn Reson Med Date: 2019-05-03 Impact factor: 4.668

Review 4. Tumor Microenvironment Biosensors for Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopy.

Authors: Changhua Mu; David E Korenchan; Sinan Wang; David M Wilson; Robert R Flavell
Journal: Mol Imaging Biol Date: 2021-01-07 Impact factor: 3.484

5. Hyperpolarized Amino Acid Derivatives as Multivalent Magnetic Resonance pH Sensor Molecules.

Authors: Christian Hundshammer; Stephan Düwel; David Ruseckas; Geoffrey Topping; Piotr Dzien; Christoph Müller; Benedikt Feuerecker; Jan B Hövener; Axel Haase; Markus Schwaiger; Steffen J Glaser; Franz Schilling
Journal: Sensors (Basel) Date: 2018-02-15 Impact factor: 3.576

6. Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer.

Authors: David E Korenchan; Robert Bok; Renuka Sriram; Kristina Liu; Romelyn Delos Santos; Hecong Qin; Iryna Lobach; Natalie Korn; David M Wilson; John Kurhanewicz; Robert R Flavell
Journal: Oncotarget Date: 2019-10-22

6 in total