Literature DB >> 28320983

Levetiracetam and topiramate poisoning: Two overdoses on those drugs with no lasting effects.

Moaziz Sarfaraz1, Rana Hasan Syeda2.   

Abstract

Levetiracetam and topiramate are newer anticonvulsants, which is why international data on overdoses of these drugs are lacking. Only a few mild adverse reactions have been noted. These anticonvulsants have been the drug of choice for neurologists. Despite their wide usage, there is a dearth of literature on symptoms and signs of their toxicity. Presented here is the case of a 21-year-old female who overdosed twice on levetiracetam and topiramate. The woman was admitted and discharged after the first overdose. Ten days later, she took multiple tablets of both drugs and was seen again. Amazingly, the woman went home after the incident with no complications at all.

Entities:  

Keywords:  Anticonvulsants; activated charcoal; gastrointestinal decontamination; seizures; toxicity

Mesh:

Substances:

Year:  2017        PMID: 28320983     DOI: 10.5582/ddt.2016.01082

Source DB:  PubMed          Journal:  Drug Discov Ther        ISSN: 1881-7831


  2 in total

1.  Multifocal myoclonus as a presentation of levetiracetam toxicity.

Authors:  Mei Bou Nasif; Shweta Varade; Mohamad Z Koubeissi
Journal:  Clin Neurophysiol Pract       Date:  2021-11-07

2.  Correlation of elevated lamotrigine and levetiracetam serum/plasma levels with toxicity: A long-term retrospective review at an academic medical center.

Authors:  Kelly E Wood; Kendra L Palmer; Matthew D Krasowski
Journal:  Toxicol Rep       Date:  2021-08-30
  2 in total

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