| Literature DB >> 28320975 |
Ninh Thi Ngoc1,2, Tran Thi Hong Hanh1, Nguyen Van Thanh1, Do Thi Thao3, Nguyen Xuan Cuong1,2, Nguyen Hoai Nam1,2, Do Cong Thung4, Phan Van Kiem1, Chau Van Minh1.
Abstract
Fifteen steroids, including two new compounds, leptosteroid (1) and 5,6β-epoxygorgosterol (2), were isolated and structurally elucidated from the Vietnamese soft coral Sinularia leptoclados. Their cytotoxic effect against a panel of eight human cancer cell lines was evaluated using sulforhodamine B (SRB) method. Significant cytotoxicity against hepatoma cancer (HepG2, IC50=21.13±0.70 µM) and colon adenocarcinoma (SW480, IC50=28.65±1.53 µM) cell lines were observed for 1 and against acute leukemia (HL-60, IC50=20.53±2.26 µM) and SW480 (IC50=26.61±1.59 µM) for ergost-5-en-3β,7β-diol (8). In addition, 3β,7β-dihydroxyergosta-5,24(28)-diene (13) showed significant cytotoxic activity on all tested cell lines with IC50 values ranging from 13.45±1.81 to 29.01±3.21 µM.Entities:
Keywords: Alcyoniidae; Sinularia leptoclados; cytotoxic activity; soft coral; steroid
Mesh：
Substances：
Year: 2017 PMID： 28320975 DOI： 10.1248/cpb.c17-00129
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645