Sinem Ozyilmaz1, Ozgur Akgul2, Huseyin Uyarel3, Hamdi Pusuroglu2, Mehmet Gul2, Muhammet Hulusi Satilmisoglu2, Ismail Bolat4, Isa Ozyilmaz5, Hakan Uçar1, Aydin Yildirim2, Ihsan Bakir6. 1. Biruni University, School of Medicine, Department of Cardiology, Istanbul, Turkey. 2. Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Cardiology, Istanbul, Turkey. 3. Bezmialem Vakıf University, School of Medicine, Department of Cardiology, Istanbul, Turkey. 4. Fethiye State Hospital, Department of Cardiology, Mugla, Turkey. 5. Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Pediatric Cardiology, Istanbul, Turkey. Electronic address: isaozyilmaz@gmail.com. 6. Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Department of Cardiovascular Surgery, Istanbul, Turkey.
Abstract
INTRODUCTION: Previous studies have demonstrated the predictive value of the neutrophil-to-lymphocyte ratio (NLR) in many cardiovascular disorders. The aim of this study was to assess whether NLR is associated with echocardiographic or electrocardiographic parameters, or with predicted five-year risk of sudden cardiac death (SCD), in patients with hypertrophic cardiomyopathy (HCM). METHODS: This prospective observational study included 74 controls and 97 HCM patients. Three years of follow-up results for HCM patients were evaluated. RESULTS: NLR was significantly higher in patients with fragmented QRS, ventricular tachycardia, and presyncope than in those without (p=0.031, 0.030, and 0.020, respectively). NLR was significantly higher in patients whose predicted five-year risk of SCD was more than 6% and whose corrected QT interval was greater than 440 ms (p=0.022 and 0.001, respectively). It was also significantly higher in patients whose left ventricular ejection fraction (LVEF) was <60% than in those with LVEF >60% (p=0.017). CONCLUSION: NLR was significantly higher in patients with HCM compared to the control group. A high NLR is associated with a higher five-year risk of SCD in patients with HCM.
INTRODUCTION: Previous studies have demonstrated the predictive value of the neutrophil-to-lymphocyte ratio (NLR) in many cardiovascular disorders. The aim of this study was to assess whether NLR is associated with echocardiographic or electrocardiographic parameters, or with predicted five-year risk of sudden cardiac death (SCD), in patients with hypertrophic cardiomyopathy (HCM). METHODS: This prospective observational study included 74 controls and 97 HCM patients. Three years of follow-up results for HCM patients were evaluated. RESULTS: NLR was significantly higher in patients with fragmented QRS, ventricular tachycardia, and presyncope than in those without (p=0.031, 0.030, and 0.020, respectively). NLR was significantly higher in patients whose predicted five-year risk of SCD was more than 6% and whose corrected QT interval was greater than 440 ms (p=0.022 and 0.001, respectively). It was also significantly higher in patients whose left ventricular ejection fraction (LVEF) was <60% than in those with LVEF >60% (p=0.017). CONCLUSION: NLR was significantly higher in patients with HCM compared to the control group. A high NLR is associated with a higher five-year risk of SCD in patients with HCM.
Keywords:
Five-year risk of sudden cardiac death; Hypertrophic cardiomyopathy; Miocardiopatia hipertrófica; Neutrophil-to-lymphocyte ratio; Relação neutrófilos/linfócitos; Score de risco a cinco anos de morte súbita cardíaca
Authors: Fátima Derlene da Rocha Araújo; Rose Mary Ferreira da Lisboa Silva; Camilla Andrade Lima Oliveira; Zilda Maria Alves Meira Journal: Ann Pediatr Cardiol Date: 2019 Jan-Apr