| Literature DB >> 2831876 |
I Y Sakharov1, E A Dukhanina, A S Molokoedov, S M Danilov, M V Ovchinnikov, Z D Bespalova, M I Titov.
Abstract
Hydrolysis of Bz-Gly-Ser-Phe-Arg, C-terminal fragment of atriopeptin 2, by human cardiac angiotensin-converting enzyme has been studied. The KM for the reaction was 10(-4) M. The effect of concentration of NaCl on activity of cardiac angiotensin-converting enzyme has been determined, which allowed to regard Bz-Gly-Ser-Phe-Arg as bradykinin-like substrates. It was demonstrated that cardiac, but not pulmonary isozyme of angiotensin-converting enzyme specifically hydrolyses atriopeptin 2.Entities:
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Year: 1988 PMID： 2831876 DOI： 10.1016/0006-291x(88)90565-7
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575