Dysfunction of sense of smell caused by canine parainfluenza virus infection in dogs.

Olfactory function of 5 dogs that were naturally infected with canine parainfluenza virus and of 4 dogs that were inoculated with the C958 strain of canine parainfluenza virus was evaluated. Except for one dog that was inoculated, the threshold for detection of benzaldehyde and/or eugenol was found to be excessively high during the course of the disease, as determined by electroencephalographic and behavioral olfactometry. In experimentally infected dogs, an increase in threshold developed in the absence of other clinical signs of disease. Changes were not observed in electro-olfactograms recorded throughout the study. Olfactory thresholds returned to normal after the disappearance of clinical signs of disease in the naturally infected dogs. Necropsies and histologic examinations performed during the course of the disease did not reveal abnormalities of the olfactory mucosa.