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Literature DB >> 28316526

Some Observations on PPI Therapy for Bleeding Ulcer.

Grigoris I Leontiadis¹, Colin W Howden¹.

Abstract

Proton pump inhibitor (PPI) therapy improves some outcomes after peptic ulcer bleeding. Recent meta-analyses have consistently found reduced rates of rebleeding and surgical intervention but there has been some discordance about effects on overall mortality. In general, more impressive results have been reported from trials conducted in Asia than elsewhere. PPI treatment for ulcer bleeding is not a substitute for appropriate endoscopic hemostatic treatment.

Entities: Disease

Keywords: Ulcer bleeding; meta-analysis; proton pump inhibitor

Year: 2006 PMID： 28316526 PMCID： PMC5350251

Source DB: PubMed Journal: Gastroenterol Hepatol (N Y) ISSN： 1554-7914

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References

20 in total

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Some Observations on PPI Therapy for Bleeding Ulcer.

1. Proton pump inhibitors in acute non-variceal upper gastrointestinal bleeding.

Review 2. Treatment with proton pump inhibitors in acute non-variceal upper gastrointestinal bleeding: a meta-analysis.

3. Continuous intravenous infusion of omeprazole in elderly patients with peptic ulcer bleeding. Results of a placebo-controlled multicenter study.

Review 4. [Intravenous omeprazole versus ranitidine in the treatment of hemorrhagic duodenal ulcer: a prospective randomized study].

5. Proton-pump inhibitors and outcome of endoscopic hemostasis in bleeding peptic ulcers: a series of meta-analyses.

6. Effect of omeprazole on the outcome of endoscopically treated bleeding peptic ulcers. Randomized double-blind placebo-controlled multicentre study.

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10. Consensus recommendations for managing patients with nonvariceal upper gastrointestinal bleeding.