Literature DB >> 28315994

Urgency and austerity as drivers of success.

Terry R Stouch1.   

Abstract

This piece describes the approach by which even a small CADD (Computer-Aided Drug Design) group with limited resources and limited time can achieve substantial success given short budgets and the compressed, urgent environment of a biotech. Some comparisons are made with CADD operations in big pharma.

Keywords:  Bristol-Myers Squibb; Clinic; Computational chemist; Computer-Aided Drug Design; Lexicon pharmaceuticals

Mesh:

Substances:

Year:  2017        PMID: 28315994     DOI: 10.1007/s10822-017-0018-5

Source DB:  PubMed          Journal:  J Comput Aided Mol Des        ISSN: 0920-654X            Impact factor:   3.686


  2 in total

1.  Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors.

Authors:  Theodore C Jessop; James E Tarver; Marianne Carlsen; Amy Xu; Jason P Healy; Alexander Heim-Riether; Qinghong Fu; Jerry A Taylor; David J Augeri; Min Shen; Terry R Stouch; Ronald V Swanson; Leslie W Tari; Michael Hunter; Isaac Hoffman; Philip E Keyes; Xuan-Chuan Yu; Maricar Miranda; Qingyun Liu; Jonathan C Swaffield; S David Kimball; Amr Nouraldeen; Alan G E Wilson; Ann Marie Digeorge Foushee; Kanchan Jhaver; Rick Finch; Steve Anderson; Tamas Oravecz; Kenneth G Carson
Journal:  Bioorg Med Chem Lett       Date:  2009-09-25       Impact factor: 2.823

2.  Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders.

Authors:  Zhi-Cai Shi; Arokiasamy Devasagayaraj; Kunjian Gu; Haihong Jin; Brett Marinelli; Lakshman Samala; Sheldon Scott; Terry Stouch; Ashok Tunoori; Ying Wang; Yi Zang; Chengmin Zhang; S David Kimball; Alan J Main; Weimei Sun; Qi Yang; Amr Nouraldeen; Xiang-Qing Yu; Eric Buxton; Shiv Patel; Nghi Nguyen; Jon Swaffield; David R Powell; Alan Wilson; Qingyun Liu
Journal:  J Med Chem       Date:  2008-06-17       Impact factor: 7.446

  2 in total

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