Lifang Pang1, Guobing Liu, Hongcheng Shi, Pengcheng Hu, Beilei Li, Dengfeng Cheng. 1. Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Nuclear Medicine Institute of Fudan University, Shanghai Institute of Medical Imaging, No. 180, Fenglin Road, Shanghai 200032, P.R. China. shi.hongcheng@zs-hospital.sh.cn.
Abstract
OBJECTIVE: To evaluate the value of fluorine -18-fuoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in evaluating synchronous multiple primary cancers (SMPC). METHODS: Nineteen patients with pathologically-confirmed SMPC were collected. Clinical and 18F-FDG PET/CT characteristics of these patients were reviewed and analyzed. Maximum standardized uptake value, (SUVmax) of all lesions was measured and difference (Δ)SUVmax between the SUV of two primary tumors in each patient was calculated as: [(the larger SUVmax - the smaller SUVmax)/ the larger SUVmax]×100%. RESULTS: A total of 38 lesions were identified, which were most frequently located in gastrointestinal tract (n=16), followed by lung (n=10), breast (n=4), kidney (n=4), liver (n=2), pancreas (n=1) and thyroid (n=1). Pathologies of these 38 lesions were 18 adenocarcinomas, 8 squamous cell carcinomas, 4 breast invasive ductal carcinomas, 4 renal cell carcinomas, 2 hepatocellular carcinomas, 1 pancreatic ductal adenocarcinoma and 1 papillary thyroid carcinoma. The mean SUVmax of all lesions was 8.5±6.9, most of them being more than 2.5 (n=30). The mean ΔSUVmax was 57.3%±24.6%, indicating different metabolism of the primary cancers in each patient. CONCLUSION: In our center, SMPC most commonly involved the gastrointestinal tract and adenocarcinomas were the most common pathology type. 18F-FDG PET/CT was useful in the diagnosis of SMPC and the ΔSUVmax indicates different pathological origins of the synchronous cancers.
OBJECTIVE: To evaluate the value of fluorine -18-fuoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in evaluating synchronous multiple primary cancers (SMPC). METHODS: Nineteen patients with pathologically-confirmed SMPC were collected. Clinical and 18F-FDG PET/CT characteristics of these patients were reviewed and analyzed. Maximum standardized uptake value, (SUVmax) of all lesions was measured and difference (Δ)SUVmax between the SUV of two primary tumors in each patient was calculated as: [(the larger SUVmax - the smaller SUVmax)/ the larger SUVmax]×100%. RESULTS: A total of 38 lesions were identified, which were most frequently located in gastrointestinal tract (n=16), followed by lung (n=10), breast (n=4), kidney (n=4), liver (n=2), pancreas (n=1) and thyroid (n=1). Pathologies of these 38 lesions were 18 adenocarcinomas, 8 squamous cell carcinomas, 4 breast invasive ductal carcinomas, 4 renal cell carcinomas, 2 hepatocellular carcinomas, 1 pancreatic ductal adenocarcinoma and 1 papillary thyroid carcinoma. The mean SUVmax of all lesions was 8.5±6.9, most of them being more than 2.5 (n=30). The mean ΔSUVmax was 57.3%±24.6%, indicating different metabolism of the primary cancers in each patient. CONCLUSION: In our center, SMPC most commonly involved the gastrointestinal tract and adenocarcinomas were the most common pathology type. 18F-FDG PET/CT was useful in the diagnosis of SMPC and the ΔSUVmax indicates different pathological origins of the synchronous cancers.