Literature DB >> 28315721

Current outcomes and predictors of treatment failure in patients with surgical site infection after elective colorectal surgery. A multicentre prospective cohort study.

Aina Gomila1, Josep Ma Badia2, Jordi Carratalà3, Xavier Serra-Aracil4, Evelyn Shaw5, Vicens Diaz-Brito6, Antoni Castro7, Elena Espejo8, Carmen Nicolás9, Marta Piriz10, Montserrat Brugués11, Josefina Obradors12, Ana Lérida13, Jordi Cuquet14, Enric Limón15, Francesc Gudiol16, Miquel Pujol17.   

Abstract

OBJECTIVE: To determine current outcomes and predictors of treatment failure among patients with surgical site infection (SSI) after colorectal surgery.
METHODS: A multicentre observational prospective cohort study of adults undergoing elective colorectal surgery in 10 Spanish hospitals (2011-2014). Treatment failure was defined as persistence of signs/symptoms of SSI or death at 30 days post-surgery.
RESULTS: Of 3701 patients, 669 (18.1%) developed SSI; 336 (9.1%) were organ-space infections. Among patients with organ-space SSI, 81.2% required source control: 60.4% reoperation and 20.8% percutaneous/transrectal drainage. Overall treatment failure rate was 21.7%: 9% in incisional SSIs and 34.2% in organ-space SSIs (p < 0.001). Median length of stay was 15 days (IQR 9-22) for incisional SSIs and 24 days (IQR 17-35) for organ-space SSIs (p < 0.001). One hundred and twenty-seven patients (19%) required readmission and 35 patients died (5.2%). Risk factors for treatment failure among patients with organ-space SSI were age ≥65 years (OR 1.83, 95% CI: 1.07-1.83), laparoscopy (OR 1.7, 95% CI: 1.06-2.77), and reoperation (OR 2.8, 95% CI: 1.7-4.6).
CONCLUSIONS: Rates of SSI and treatment failure in organ-space SSI after elective colorectal surgery are notably high. Careful attention should be paid to older patients with previous laparoscopy requiring reoperation for organ-space SSI, so that treatment failure can be identified early.
Copyright © 2017 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Colorectal diseases; Multidrug-resistant Gram-negative bacilli; Organ-space surgical site infections; Surgical site infections

Mesh:

Substances:

Year:  2017        PMID: 28315721     DOI: 10.1016/j.jinf.2017.03.002

Source DB:  PubMed          Journal:  J Infect        ISSN: 0163-4453            Impact factor:   6.072


  5 in total

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Authors:  K T Park; L Sceats; M Dehghan; A W Trickey; A Wren; J J Wong; R Bensen; B N Limketkai; K Keyashian; C Kin
Journal:  Aliment Pharmacol Ther       Date:  2018-06-07       Impact factor: 8.171

2.  Local antimicrobial delivery from temperature-responsive hydrogels reduces incidence of intra-abdominal infection in rats.

Authors:  John M Heffernan; Alex C McLaren; Derek J Overstreet
Journal:  Comp Immunol Microbiol Infect Dis       Date:  2022-05-13       Impact factor: 2.729

3.  Influence of Enhanced Recovery Pathway on Surgical Site Infection after Colonic Surgery.

Authors:  Caroline Gronnier; Fabian Grass; Christiane Petignat; Basile Pache; Dieter Hahnloser; Giorgio Zanetti; Nicolas Demartines; Martin Hübner
Journal:  Gastroenterol Res Pract       Date:  2017-10-31       Impact factor: 2.260

4.  Preoperative oral antibiotic prophylaxis reduces Pseudomonas aeruginosa surgical site infections after elective colorectal surgery: a multicenter prospective cohort study.

Authors:  A Gomila; J Carratalà; J M Badia; D Camprubí; M Piriz; E Shaw; V Diaz-Brito; E Espejo; C Nicolás; M Brugués; R Perez; A Lérida; A Castro; S Biondo; D Fraccalvieri; E Limón; F Gudiol; M Pujol
Journal:  BMC Infect Dis       Date:  2018-10-05       Impact factor: 3.090

5.  Study protocol for the groin wound infection after vascular exposure (GIVE) audit and multicentre cohort study.

Authors:  Brenig Llwyd Gwilym; Athanasios Saratzis; Ruth Benson; Rachael Forsythe; George Dovell; Nikesh Dattani; Tristan Lane; Ryan Preece; Joseph Shalhoub; David Charles Bosanquet
Journal:  Int J Surg Protoc       Date:  2019-07-26
  5 in total

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