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Literature DB >> 28315447

Cyclosporine A delivery to the eye: A comprehensive review of academic and industrial efforts.

Frédéric Lallemand¹, Mathieu Schmitt¹, Jean-Louis Bourges², Robert Gurny³, Simon Benita⁴, Jean-Sébastien Garrigue⁵.

Abstract

Local ocular delivery of cyclosporine A (CsA) is the preferred method for CsA delivery as a treatment for ocular inflammatory diseases such as uveitis, corneal healing, vernal keratoconjunctivitis and dry eye disease. However, due to the large molecular weight and hydrophobic nature of CsA and the natural protective mechanisms of the eye, achieving therapeutic levels of CsA in ocular tissues can be difficult. This review gives a comprehensive overview of the current products available to clinicians as well as emerging drug delivery solutions that have been developed at both the academic and industry levels.

Entities: Chemical Disease

Keywords: Cyclosporine; Emulsion; Hydrogel; Ocular delivery; Pipeline products; Solution

Mesh：

Substances：

Year: 2017 PMID： 28315447 DOI： 10.1016/j.ejpb.2017.03.006

Source DB: PubMed Journal: Eur J Pharm Biopharm ISSN： 0939-6411 Impact factor: 5.571

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Cited

39 in total

Review 1. Therapeutic implications of nanomedicine for ocular drug delivery.

Authors: Tuo Meng; Vineet Kulkarni; Russell Simmers; Vikram Brar; Qingguo Xu
Journal: Drug Discov Today Date: 2019-05-15 Impact factor: 7.851

2. Biodegradable Thermosensitive PLGA-PEG-PLGA Polymer for Non-irritating and Sustained Ophthalmic Drug Delivery.

Authors: Pui Shan Chan; Jia Wen Xian; Qingqing Li; Chun Wai Chan; Sharon S Y Leung; Kenneth K W To
Journal: AAPS J Date: 2019-04-24 Impact factor: 4.009

Review 3. Recent advances in cyclosporine drug delivery: challenges and opportunities.

Authors: Dhrumi Patel; Sarika Wairkar
Journal: Drug Deliv Transl Res Date: 2019-12 Impact factor: 4.617

4. [Effect of topical injection of cyclosporine A on saliva secretion and inflammation in the submandibular gland of non-obese diabetic mice].

Authors: Y Y Zhu; S N Min; G Y Yu
Journal: Beijing Da Xue Xue Bao Yi Xue Ban Date: 2021-08-18

10. Drug-Integrating Amphiphilic Nanomaterial Assemblies: 1. Spatiotemporal control of cyclosporine delivery and activity using nanomicelles and nanofibrils.

Authors: Diana Velluto; Damir Bojadzic; Teresa De Toni; Peter Buchwald; Alice A Tomei
Journal: J Control Release Date: 2020-10-18 Impact factor: 9.776

Cyclosporine A delivery to the eye: A comprehensive review of academic and industrial efforts.

Review 1. Therapeutic implications of nanomedicine for ocular drug delivery.

2. Biodegradable Thermosensitive PLGA-PEG-PLGA Polymer for Non-irritating and Sustained Ophthalmic Drug Delivery.

Review 3. Recent advances in cyclosporine drug delivery: challenges and opportunities.

4. [Effect of topical injection of cyclosporine A on saliva secretion and inflammation in the submandibular gland of non-obese diabetic mice].

Review 5. Ciclosporin Ophthalmic Emulsion 0.1%: A Review in Severe Dry Eye Disease.

6. Posaconazole micelles for ocular delivery: in vitro permeation, ocular irritation and antifungal activity studies.

7. Cyclosporine reduces the spleen dimensions in rabbits.

8. Dry Eye Treatment with Topical Cyclosporine 0.1% in Chondroitin Sulfate Ophthalmic Emulsion.

Review 9. Peptidomimetics Therapeutics for Retinal Disease.

10. Drug-Integrating Amphiphilic Nanomaterial Assemblies: 1. Spatiotemporal control of cyclosporine delivery and activity using nanomicelles and nanofibrils.