Literature DB >> 28314894

Development of anticancer agents targeting the Hedgehog signaling.

Xiangqian Zhang1, Ye Tian1, Yanling Yang2, Jijun Hao3,4.   

Abstract

Hedgehog signaling is an evolutionarily conserved pathway which is essential in embryonic and postnatal development as well as adult organ homeostasis. Abnormal regulation of Hedgehog signaling is implicated in many diseases including cancer. Consequently, substantial efforts have made in the past to develop potential therapeutic agents that specifically target the Hedgehog signaling for cancer treatment. Here, we review the therapeutic agents for inhibition of the Hedgehog signaling and their clinical advances in cancer treatment.

Entities:  

Keywords:  Cancer; Drugs; Hedgehog signaling; Patched; Safety and clinic; Small molecules; Smothern; Therapeutic

Mesh：

Substances：

Year:  2017        PMID： 28314894     DOI： 10.1007/s00018-017-2497-x

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  110 in total

1.  The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.

Authors:  Ivan Bosanac; Henry R Maun; Suzie J Scales; Xiaohui Wen; Andreas Lingel; J Fernando Bazan; Frederic J de Sauvage; Sarah G Hymowitz; Robert A Lazarus
Journal:  Nat Struct Mol Biol       Date:  2009-06-28       Impact factor: 15.369

2.  Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF.

Authors:  S S Pullamsetti; G A Banat; A Schmall; M Szibor; D Pomagruk; J Hänze; E Kolosionek; J Wilhelm; T Braun; F Grimminger; W Seeger; R T Schermuly; R Savai
Journal:  Oncogene       Date:  2012-04-23       Impact factor: 9.867

Review 3.  Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

Authors:  Suzie J Scales; Frederic J de Sauvage
Journal:  Trends Pharmacol Sci       Date:  2009-05-13       Impact factor: 14.819

4.  Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.

Authors:  Matthias Lauth; Asa Bergström; Takashi Shimokawa; Rune Toftgård
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-09       Impact factor: 11.205

Review 5.  Opportunities for Trisenox (arsenic trioxide) in the treatment of myelodysplastic syndromes.

Authors:  A List; M Beran; J DiPersio; J Slack; N Vey; C S Rosenfeld; P Greenberg
Journal:  Leukemia       Date:  2003-08       Impact factor: 11.528

6.  A paracrine requirement for hedgehog signalling in cancer.

Authors:  Robert L Yauch; Stephen E Gould; Suzie J Scales; Tracy Tang; Hua Tian; Christina P Ahn; Derek Marshall; Ling Fu; Thomas Januario; Dara Kallop; Michelle Nannini-Pepe; Karen Kotkow; James C Marsters; Lee L Rubin; Frederic J de Sauvage
Journal:  Nature       Date:  2008-08-27       Impact factor: 49.962

7.  Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling.

Authors:  Elissaveta Petrova; Jessica Rios-Esteves; Ouathek Ouerfelli; J Fraser Glickman; Marilyn D Resh
Journal:  Nat Chem Biol       Date:  2013-02-17       Impact factor: 15.040

8.  Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma.

Authors:  Xuecai Ge; Ljiljana Milenkovic; Kaye Suyama; Tom Hartl; Teresa Purzner; Amy Winans; Tobias Meyer; Matthew P Scott
Journal:  Elife       Date:  2015-09-15       Impact factor: 8.140

9.  Down-regulation of Gli transcription factor leads to the inhibition of migration and invasion of ovarian cancer cells via integrin β4-mediated FAK signaling.

Authors:  Qi Chen; Rong Xu; Chunyan Zeng; Quqin Lu; Dengliang Huang; Chao Shi; Weilong Zhang; Libin Deng; Runwei Yan; Hai Rao; Guolan Gao; Shiwen Luo
Journal:  PLoS One       Date:  2014-02-12       Impact factor: 3.240

10.  Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells.

Authors:  Nobuaki Fukushima; Yosuke Minami; Seiji Kakiuchi; Yachiyo Kuwatsuka; Fumihiko Hayakawa; Catoriona Jamieson; Hitoshi Kiyoi; Tomoki Naoe
Journal:  Cancer Sci       Date:  2016-09-02       Impact factor: 6.716
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  3 in total

1.  Bone marrow mesenchymal stromal cells attenuate silica-induced pulmonary fibrosis potentially by attenuating Wnt/β-catenin signaling in rats.

Authors:  Enguo Zhang; Ye Yang; Shangya Chen; Cheng Peng; Martin F Lavin; Abrey J Yeo; Chao Li; Xiaoshan Liu; Yingjun Guan; Xinjing Du; Zhongjun Du; Hua Shao
Journal:  Stem Cell Res Ther       Date:  2018-11-14       Impact factor: 6.832

2.  A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth.

Authors:  Ludovica Lospinoso Severini; Deborah Quaglio; Irene Basili; Francesca Ghirga; Francesca Bufalieri; Miriam Caimano; Silvia Balducci; Marta Moretti; Isabella Romeo; Elena Loricchio; Marella Maroder; Bruno Botta; Mattia Mori; Paola Infante; Lucia Di Marcotullio
Journal:  Cancers (Basel)       Date:  2019-10-09       Impact factor: 6.639

3.  Gemcitabine-induced Gli-dependent activation of hedgehog pathway resists to the treatment of urothelial carcinoma cells.

Authors:  Yu-Hao Chang; Hoi-Lam Tam; Meng-Chien Lu; Huei-Sheng Huang
Journal:  PLoS One       Date:  2021-07-08       Impact factor: 3.240
  3 in total

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