Kiyotaka Yoh1, Yasushi Goto2, Yoichi Naito3, Kazuma Kishi4, Kiyoshi Mori5, Katsuyuki Hotta6, Yukio Hosomi7, Kazuhiko Yamada8, Chiharu Tanai9, Yoshio Tomizawa10, Akira Inoue11, Yoshinori Hasegawa12, Makoto Nishio13, Yasuo Ohashi14, Hideo Kunitoh15. 1. Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan kyoh@east.ncc.go.jp. 2. Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan. 3. Department of Breast and Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan. 4. Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Tokyo, Japan. 5. Department of Thoracic Disease, Tsuboi Cancer Center Hospital, Koriyama, Japan. 6. Department of Respiratory Medicine, Okayama University Hospital, Okayama, Japan. 7. Department of Thoracic Oncology and Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan. 8. Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan. 9. Division of Respirology, NTT Medical Center Tokyo, Tokyo, Japan. 10. Department of Respiratory Medicine, National Hospital Organization Nishigunma Hospital, Gunma, Japan. 11. Department of Palliative Medicine, Tohoku University School of Medicine, Sendai, Japan. 12. Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan. 13. Department of Thoracic Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan. 14. Department of Integrated Science and Engineering for Sustainable Society, Chuo University, Tokyo, Japan. 15. Department of Medical Oncology, Japanese Red Cross Medical Center, Tokyo, Japan.
Abstract
BACKGROUND: The purpose of this study was to explore the role of maintenance therapy for patients with advanced non-small cell lung cancer (NSCLC) in a real-world setting. PATIENTS AND METHODS: This was a prospective observational cohort multicenter study. Eligible patients were observed from initiation of first-line platinum-based chemotherapy until final follow-up. RESULTS: Between 2010 and 2011, a total of 864 patients were enrolled in this study. The primary study population was 396 patients who had progressive disease during observation after first-line chemotherapy without maintenance. Of these, 113 patients (29%) did not receive second-line therapy. In contrast, only 18% of patients who had progressive disease during maintenance therapy missed second-line therapy. Overall survival of patients without maintenance who received second-line therapy was similar to that of those who received maintenance, but no second-line therapy. CONCLUSION: Maintenance therapy for patients with advanced NSCLC might be an appropriate strategy to maximize the chance of receiving more active therapy. Copyright
BACKGROUND: The purpose of this study was to explore the role of maintenance therapy for patients with advanced non-small cell lung cancer (NSCLC) in a real-world setting. PATIENTS AND METHODS: This was a prospective observational cohort multicenter study. Eligible patients were observed from initiation of first-line platinum-based chemotherapy until final follow-up. RESULTS: Between 2010 and 2011, a total of 864 patients were enrolled in this study. The primary study population was 396 patients who had progressive disease during observation after first-line chemotherapy without maintenance. Of these, 113 patients (29%) did not receive second-line therapy. In contrast, only 18% of patients who had progressive disease during maintenance therapy missed second-line therapy. Overall survival of patients without maintenance who received second-line therapy was similar to that of those who received maintenance, but no second-line therapy. CONCLUSION: Maintenance therapy for patients with advanced NSCLC might be an appropriate strategy to maximize the chance of receiving more active therapy. Copyright
Authors: Edward B Garon; Giorgio Vittorio Scagliotti; Oliver Gautschi; Martin Reck; Michael Thomas; Lara Iglesias Docampo; Haralabos Kalofonos; Joo-Hang Kim; Steven Gans; Odd Terje Brustugun; Sergey V Orlov; Gebra Cuyun Carter; Annamaria H Zimmermann; Ana B Oton; Ekaterine Alexandris; Pablo Lee; Katharina Wolff; Victoria Jennifer Stefaniak; Mark A Socinski; Maurice Pérol Journal: ESMO Open Date: 2020-01