In Hee Lee1, Soyoon Hwang1, Soo Jung Lee1, Byung Woog Kang1, Dongwon Baek1, Hye Jin Kim2, Su Yeon Park2, Jun Seok Park2, Gyu Seog Choi2, Jae Chul Kim3, Seung Hyun Cho4, Jong Gwang Kim5. 1. Department of Oncology/Hematology, Kyungpook National University Medical Center, Kyungpook National University School of Medicine, Kyungpook National University Cancer Research Institute, Daegu, Republic of Korea. 2. Department of Surgery, Kyungpook National University Medical Center, Kyungpook National University School of Medicine, Daegu, Republic of Korea. 3. Department of Radiation oncology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Republic of Korea. 4. Department of Radiology, Kyungpook National University Medical Center, Kyungpook National University School of Medicine, Daegu, Republic of Korea. 5. Department of Oncology/Hematology, Kyungpook National University Medical Center, Kyungpook National University School of Medicine, Kyungpook National University Cancer Research Institute, Daegu, Republic of Korea jkk21c@knu.ac.kr.
Abstract
AIM: Systemic inflammatory response (SIR) has been reported to be an important determinant of disease progression and survival in patients with colorectal cancer. This study investigated the prognostic relevance of changes in the platelet count on survival and the predictive value of changes in platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR) on the pathological tumor response to preoperative chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC). PATIENTS AND METHODS: From 2006 to 2015, 291 consecutive patients with LARC who were treated with preoperative CRT followed by curative surgery at the Kyungpook National University Medical Center (Daegu, Korea) were retrospectively analyzed. A cut-off value of 370×103/μl for the platelet count was used and a PLR ≥235 was defined as high. Any change in the PLR or NLR was calculated based on subtracting the pre-CRT PLR or NLR from the post-CRT values. RESULTS: A total of 17.5% patients had stage II and 82.5% had stage III LARC. Initially high NLR and PLR were significantly associated with poor clinical outcomes. Patients who maintained a high platelet count after CRT also had an advanced pathological stage (p=0.028), low pathological complete response rate (p=0.048), and high relapse rate (p=0.021). For patients with an initially low PLR, the multiple logistic regression analysis revealed that a high PLR change (odds ratio (OR)=2.301, 95% confidence interval (CI)=1.269-4.174; p=0.006) and clinical stage II compared to stage III (OR=1.878, 95% CI=1.231-2.865; p=0.003) were significant independent markers predictive of a good response to CRT. CONCLUSION: The present results suggest that platelet and PLR change after preoperative CRT, along with the initial platelet count, can be used as prognostic and predictive markers for the oncological outcomes in patients with LARC. Copyright
AIM: Systemic inflammatory response (SIR) has been reported to be an important determinant of disease progression and survival in patients with colorectal cancer. This study investigated the prognostic relevance of changes in the platelet count on survival and the predictive value of changes in platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR) on the pathological tumor response to preoperative chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC). PATIENTS AND METHODS: From 2006 to 2015, 291 consecutive patients with LARC who were treated with preoperative CRT followed by curative surgery at the Kyungpook National University Medical Center (Daegu, Korea) were retrospectively analyzed. A cut-off value of 370×103/μl for the platelet count was used and a PLR ≥235 was defined as high. Any change in the PLR or NLR was calculated based on subtracting the pre-CRT PLR or NLR from the post-CRT values. RESULTS: A total of 17.5% patients had stage II and 82.5% had stage III LARC. Initially high NLR and PLR were significantly associated with poor clinical outcomes. Patients who maintained a high platelet count after CRT also had an advanced pathological stage (p=0.028), low pathological complete response rate (p=0.048), and high relapse rate (p=0.021). For patients with an initially low PLR, the multiple logistic regression analysis revealed that a high PLR change (odds ratio (OR)=2.301, 95% confidence interval (CI)=1.269-4.174; p=0.006) and clinical stage II compared to stage III (OR=1.878, 95% CI=1.231-2.865; p=0.003) were significant independent markers predictive of a good response to CRT. CONCLUSION: The present results suggest that platelet and PLR change after preoperative CRT, along with the initial platelet count, can be used as prognostic and predictive markers for the oncological outcomes in patients with LARC. Copyright
Authors: Alexander D Sherry; Rie von Eyben; Neil B Newman; Paulina Gutkin; Ingrid Mayer; Kathleen Horst; A Bapsi Chakravarthy; Marjan Rafat Journal: Int J Radiat Oncol Biol Phys Date: 2019-12-03 Impact factor: 7.038
Authors: Claudio Belluco; Marco Forlin; Paolo Delrio; Daniela Rega; Maurizio Degiuli; Silvia Sofia; Matteo Olivieri; Salvatore Pucciarelli; Matteo Zuin; Giovanni De Manzoni; Alberto Di Leo; Stefano Scabini; Luigi Zorcolo; Angelo Restivo Journal: BMC Cancer Date: 2018-11-12 Impact factor: 4.430
Authors: Ross D Dolan; Muhammed Alwahid; Stephen T McSorley; James H Park; Richard P Stevenson; Campbell S Roxburgh; Paul G Horgan; Donald C McMillan Journal: Sci Rep Date: 2020-10-21 Impact factor: 4.379