Michele Scialpi1, Enrico Prosperi2, Alfredo D'Andrea3, Eugenio Martorana4, Corrado Malaspina5, Barbara Palumbo5, Agostino Orlandi5, Giuseppe Falcone5, Michele Milizia5, Luigi Mearini6, Maria Cristina Aisa7, Pietro Scialpi8, Carlo DE Dominicis9, Giampaolo Bianchi4, Angelo Sidoni2. 1. Division of Radiology 2 and Nuclear Medicine, S. Maria della Misericordia Hospital, Perugia University, Perugia, Italy michelescialpi1@gmail.com. 2. Section of Anatomic Pathology and Histology, Department of Surgical and Biomedical Sciences, S. Maria della Misericordia Hospital, Perugia University, Perugia, Italy. 3. Division of Radiology, San Giuseppe Moscati Hospital, Aversa, Italy. 4. Department of Urology, University of Modena, Modena, Italy. 5. Division of Radiology 2 and Nuclear Medicine, S. Maria della Misericordia Hospital, Perugia University, Perugia, Italy. 6. Division of Urology, S. Maria della Misericordia Hospital, Perugia University, Perugia, Italy. 7. Division of Gynaecology, S. Maria della Misericordia Hospital, Perugia University, Perugia, Italy. 8. Division of Urology, Portogruaro, Venice, Italy. 9. Department of Gynaecology and Obstetric Science and Urologic Science, La Sapienza University of Rome, Rome, Italy.
Abstract
AIM: To assess the sensitivity of biparametric magnetic resonance imaging (bpMRI) with non-endorectal coil in the detection and localization of index (dominant) and non-index lesions in patients suspected of having prostate cancer. PATIENTS AND METHODS: We carried-out a retrospective analysis of multiparametric MRI (mpMRI) of 41 patients who underwent radical prostatectomy. Results of MRI for detection and localization of index and non-index lesions were correlated with those of histology. RESULTS: No statistically significant difference in size was seen between tumor lesion at histology and index lesion at MRI. In 41 patients, a total of 131 tumors were identified at histology, while bpMRI (T2-weighted and diffusion-weighted MRI) approach detected 181 lesions. bpMRI gave 27.6% false-positives and 3.3% false-negatives. Sensitivity in lesion detection by bpMRI increased with lesion size assuming high values for lesions ≥10 mm. For bpMRI and mpMRI, the sensitivity for detecting index lesions was the same and equal: 100% in the peripheral zone 97.6% and 94.7% in the entire prostate and transitional zone, respectively. CONCLUSION: bpMRI can be used alternatively to mpMRI to detect and localize index prostate cancer. Copyright
AIM: To assess the sensitivity of biparametric magnetic resonance imaging (bpMRI) with non-endorectal coil in the detection and localization of index (dominant) and non-index lesions in patients suspected of having prostate cancer. PATIENTS AND METHODS: We carried-out a retrospective analysis of multiparametric MRI (mpMRI) of 41 patients who underwent radical prostatectomy. Results of MRI for detection and localization of index and non-index lesions were correlated with those of histology. RESULTS: No statistically significant difference in size was seen between tumor lesion at histology and index lesion at MRI. In 41 patients, a total of 131 tumors were identified at histology, while bpMRI (T2-weighted and diffusion-weighted MRI) approach detected 181 lesions. bpMRI gave 27.6% false-positives and 3.3% false-negatives. Sensitivity in lesion detection by bpMRI increased with lesion size assuming high values for lesions ≥10 mm. For bpMRI and mpMRI, the sensitivity for detecting index lesions was the same and equal: 100% in the peripheral zone 97.6% and 94.7% in the entire prostate and transitional zone, respectively. CONCLUSION: bpMRI can be used alternatively to mpMRI to detect and localize index prostate cancer. Copyright
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