Literature DB >> 2831099

Direct photoaffinity labeling of the putative sulfonylurea receptor in rat beta-cell tumor membranes by [3H]glibenclamide.

W Kramer1, R Oekonomopulos, J Pünter, H D Summ.   

Abstract

The oral antidiabetic sulfonylurea [3H]glibenclamide specifically binds to plasma membranes from a rat beta-cell tumor indicating a receptor for sulfonylureas in these membranes. Irradiation of [3H]glibenclamide at 254 or 300 nm in the presence of albumin resulted in covalent labeling of the albumin molecule. Direct photoaffinity labeling of beta-cell membranes with [3H]glibenclamide resulted in the covalent modification of two membrane polypeptides with apparent molecular masses 140 and 33 kDa. The extent of labeling of the 140 kDa polypeptide was specifically decreased by sulfonylureas. This suggests that a membrane polypeptide of 140 kDa is a component of the sulfonylurea receptor in the beta-cell membrane.

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Year:  1988        PMID： 2831099     DOI： 10.1016/0014-5793(88)81155-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  15 in total

1.  Cardiac sulfonylurea receptor short form-based channels confer a glibenclamide-insensitive KATP activity.

Authors:  Jie-Lin Pu; Bin Ye; Stacie L Kroboth; Elizabeth M McNally; Jonathan C Makielski; Nian-Qing Shi
Journal:  J Mol Cell Cardiol       Date:  2007-09-29       Impact factor: 5.000

Review 2.  Pharmacology and regulation of ATP-sensitive K+ channels.

Authors:  J R de Weille; M Fosset; C Mourre; H Schmid-Antomarchi; H Bernardi; M Lazdunski
Journal:  Pflugers Arch       Date:  1989       Impact factor: 3.657

3.  Effects of glimepiride on insulin and glucagon release from isolated rat pancreas at different glucose concentrations.

Authors:  F Gregorio; F Ambrosi; S Cristallini; P Filipponi; F Santeusanio
Journal:  Acta Diabetol       Date:  1996-03       Impact factor: 4.280

4.  Intracellular localization and molecular heterogeneity of the sulphonylurea receptor in insulin-secreting cells.

Authors:  S E Ozanne; P C Guest; J C Hutton; C N Hales
Journal:  Diabetologia       Date:  1995-03       Impact factor: 10.122

5.  Tolbutamide excites rat glucoreceptive ventromedial hypothalamic neurones by indirect inhibition of ATP-K+ channels.

Authors:  M L Ashford; P R Boden; J M Treherne
Journal:  Br J Pharmacol       Date:  1990-11       Impact factor: 8.739

6.  ATP-sensitive K-channels in HIT T15 beta-cells studied by patch-clamp methods, 86Rb efflux and glibenclamide binding.

Authors:  I Niki; R P Kelly; S J Ashcroft; F M Ashcroft
Journal:  Pflugers Arch       Date:  1989-10       Impact factor: 3.657

7.  ATP-modulated K+ channels sensitive to antidiabetic sulfonylureas are present in adenohypophysis and are involved in growth hormone release.

Authors:  H Bernardi; J R De Weille; J Epelbaum; C Mourre; S Amoroso; A Slama; M Fosset; M Lazdunski
Journal:  Proc Natl Acad Sci U S A       Date:  1993-02-15       Impact factor: 11.205

8.  The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein.

Authors:  S Barg; E Renström; P O Berggren; A Bertorello; K Bokvist; M Braun; L Eliasson; W E Holmes; M Köhler; P Rorsman; F Thévenod
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-11       Impact factor: 11.205

9.  Characterization of the solubilized glibenclamide receptor in a hamster pancreatic beta-cell line, HIT T15.

Authors:  I Niki; M Welsh; P O Berggren; P Hubbard; S J Ashcroft
Journal:  Biochem J       Date:  1991-08-01       Impact factor: 3.857

10.  Characterization, purification, and affinity labeling of the brain [3H]glibenclamide-binding protein, a putative neuronal ATP-regulated K+ channel.

Authors:  H Bernardi; M Fosset; M Lazdunski
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205
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