Literature DB >> 2831081

Tissue plasminogen activator mRNA in murine tissues.

R J Rickles1, S Strickland.   

Abstract

The urokinase-type and tissue-type plasminogen activators are the two enzymes found in mammals, which specifically convert the zymogen plasminogen to plasmin. Using cDNA probes, we have assayed for the presence of the two types of plasminogen activator mRNAs in murine tissues. We demonstrate that tissue-type plasminogen activator mRNA can be detected in a wide variety of tissues. In contrast, the accumulation of urokinase-type plasminogen activator mRNA is observed in only a few of the tissues analyzed. Using an S1 nuclease assay, we demonstrate that the tPA mRNA detected contains the complete sequences encoding the non-protease finger, growth-factor and kringle domains.

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Year:  1988        PMID： 2831081     DOI： 10.1016/0014-5793(88)80806-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

1.  Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin.

Authors:  S E Tsirka; T H Bugge; J L Degen; S Strickland
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-02       Impact factor: 11.205

2.  Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator.

Authors:  T H Bugge; M J Flick; M J Danton; C C Daugherty; J Romer; K Dano; P Carmeliet; D Collen; J L Degen
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-11       Impact factor: 11.205

3.  Increased gene expression of plasminogen activators and inhibitors in left ventricular hypertrophy.

Authors:  C M Bloor; L Nimmo; M D McKirnan; Y Zhang; F C White
Journal:  Mol Cell Biochem       Date:  1997-11       Impact factor: 3.396

4.  In vitro analysis of the tissue plasminogen activator promoter reveals a GC box-binding activity present in murine brain but undetectable in kidney and liver.

Authors:  L T Pecorino; A L Darrow; S Strickland
Journal:  Mol Cell Biol       Date:  1991-06       Impact factor: 4.272

5.  An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus.

Authors:  S E Tsirka; A D Rogove; T H Bugge; J L Degen; S Strickland
Journal:  J Neurosci       Date:  1997-01-15       Impact factor: 6.167

6.  Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse.

Authors:  M A Olman; N Mackman; C L Gladson; K M Moser; D J Loskutoff
Journal:  J Clin Invest       Date:  1995-09       Impact factor: 14.808

7.  Fibrin deposition in tissues from endotoxin-treated mice correlates with decreases in the expression of urokinase-type but not tissue-type plasminogen activator.

Authors:  K Yamamoto; D J Loskutoff
Journal:  J Clin Invest       Date:  1996-06-01       Impact factor: 14.808

8.  Tissue plasminogen activator is a potent activator of PDGF-CC.

Authors:  Linda Fredriksson; Hong Li; Christina Fieber; Xuri Li; Ulf Eriksson
Journal:  EMBO J       Date:  2004-09-16       Impact factor: 11.598

9.  Transcriptional regulation of the rat tissue type plasminogen activator gene: localization of DNA elements and nuclear factors mediating constitutive and cyclic AMP-induced expression.

Authors:  M Ohlsson; G Leonardsson; X C Jia; P Feng; T Ny
Journal:  Mol Cell Biol       Date:  1993-01       Impact factor: 4.272

10.  Sites of synthesis of urokinase and tissue-type plasminogen activators in the murine kidney.

Authors:  A P Sappino; J Huarte; J D Vassalli; D Belin
Journal:  J Clin Invest       Date:  1991-03       Impact factor: 14.808
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