Literature DB >> 2831074

The signal transducing system coupled to serotonin-S2 receptors.

D de Chaffoy de Courcelles1, J E Leysen, F de Clerck.   

Abstract

The signal transducing system coupled to the serotonin-S2 receptor on platelets involves metabolism of inositol-containing phospholipid, elevation of intracellular free Ca2+ and activation of protein kinase C. Evidence for coupling of the serotonin-S2 receptor to the same signal transducing system in brain and smooth muscle tissue is reviewed.

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Year:  1988        PMID： 2831074     DOI： 10.1007/BF01952195

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  22 in total

1.  5-Hydroxytryptamine-2 antagonist increases human slow wave sleep.

Authors:  C Idzikowski; F J Mills; R Glennard
Journal:  Brain Res       Date:  1986-07-16       Impact factor: 3.252

2.  Cytosolic calcium elevation and cGMP production induced by serotonin in a clonal cell of glial origin.

Authors:  A Ogura; K Ozaki; Y Kudo; T Amano
Journal:  J Neurosci       Date:  1986-09       Impact factor: 6.167

3.  Regulation of serotonin-stimulated phosphoinositide hydrolysis: relation to the serotonin 5-HT-2 binding site.

Authors:  P J Conn; E Sanders-Bush
Journal:  J Neurosci       Date:  1986-12       Impact factor: 6.167

4.  Effects of dopamine, gamma-aminobutyric acid and 5-hydroxytryptamine on incorporation of 32P into phosphatides in slices from the guinea pig brain.

Authors:  M R Hokin
Journal:  J Neurochem       Date:  1970-03       Impact factor: 5.372

5.  Influence of Ca2+e on 5-HT2- and alpha 1-induced arterial contraction and phosphoinositide metabolism.

Authors:  P Berta; J Seguin; N Vidal; J Haiech; M N Mathieu; C Chevillard
Journal:  Eur J Pharmacol       Date:  1986-12-16       Impact factor: 4.432

6.  Serotonin-induced alterations in inositol phospholipid metabolism in human platelets.

Authors:  D de Chaffoy de Courcelles; P Roevens; J Wynants; H Van Belle
Journal:  Biochim Biophys Acta       Date:  1987-02-18

7.  Serotonin-stimulated phosphoinositide turnover: mediation by the S2 binding site in rat cerebral cortex but not in subcortical regions.

Authors:  P J Conn; E Sanders-Bush
Journal:  J Pharmacol Exp Ther       Date:  1985-07       Impact factor: 4.030

8.  Serotonin-elicited amplification of adenylate cyclase activity in hippocampal membranes from adult rat.

Authors:  M L Barbaccia; N Brunello; D M Chuang; E Costa
Journal:  J Neurochem       Date:  1983-06       Impact factor: 5.372

Review 9.  Inositol trisphosphate, a novel second messenger in cellular signal transduction.

Authors:  M J Berridge; R F Irvine
Journal:  Nature       Date:  1984 Nov 22-28       Impact factor: 49.962

10.  Evidence that phospholipid turnover is the signal transducing system coupled to serotonin-S2 receptor sites.

Authors:  D de Chaffoy de Courcelles; J E Leysen; F De Clerck; H Van Belle; P A Janssen
Journal:  J Biol Chem       Date:  1985-06-25       Impact factor: 5.157
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