Eugene Chang1, Lalitha Nayak, Mukesh K Jain. 1. Case Cardiovascular Research Institute, Case Western Reserve University, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Abstract
PURPOSE OF REVIEW: Krüppel-like factors (KLFs) are a family of transcription factors that regulate integral functions of endothelial cells including inflammation, proliferation, growth, apoptosis, cell differentiation and plasticity, and migration. This review will focus on the role of KLFs in physiological activity and their loss in vascular pathology. RECENT FINDINGS: New studies have pointed at the role of microRNAs as repressors of KLFs in atherosclerotic areas providing another level of signaling regulation of KLFs. SUMMARY: KLFs are important regulators of almost all facets of endothelial biology, making them a promising therapeutic target in the treatment of endothelial dysfunction and cardiovascular disease. Further research is needed to fully characterize their functions.
PURPOSE OF REVIEW: Krüppel-like factors (KLFs) are a family of transcription factors that regulate integral functions of endothelial cells including inflammation, proliferation, growth, apoptosis, cell differentiation and plasticity, and migration. This review will focus on the role of KLFs in physiological activity and their loss in vascular pathology. RECENT FINDINGS: New studies have pointed at the role of microRNAs as repressors of KLFs in atherosclerotic areas providing another level of signaling regulation of KLFs. SUMMARY: KLFs are important regulators of almost all facets of endothelial biology, making them a promising therapeutic target in the treatment of endothelial dysfunction and cardiovascular disease. Further research is needed to fully characterize their functions.
Authors: Roman Tsaryk; Nora Yucel; Elvin V Leonard; Noelia Diaz; Olga Bondareva; Maria Odenthal-Schnittler; Zoltan Arany; Juan M Vaquerizas; Hans Schnittler; Arndt F Siekmann Journal: Sci Rep Date: 2022-03-21 Impact factor: 4.379