Na Young Lee1,2, Min Hee Kim1,3, Chan Kee Park1,4. 1. a College of Medicine , The Catholic University of Korea , Seoul , Korea. 2. b Department of Ophthalmology , Incheon St. Mary's Hospital , Incheon , Korea. 3. c Department of Ophthalmology , Yeouido St. Mary's Hospital , Seoul , Korea. 4. d Department of Ophthalmology , Seoul St. Mary's Hospital , Seoul , Korea.
Abstract
PURPOSE: To investigate the associations between endothelin-1 (ET-1) and macrophage chemoattractant protein-1 (MCP-1) levels and visual field (VF) progression in normal-tension glaucoma (NTG). METHODS: We conducted a prospective, longitudinal study in 71 patients with NTG. Blood samples from all subjects were assayed for ET-1 and MCP-1 concentrations, and baseline ophthalmic examinations, including the VF, were performed. Baseline data were compared with follow-up data over 3 years. RESULTS: After 3 years of follow-up, 14 of the 71 patients showed VF progression, and the systemic MCP-1 level was significantly associated with VF progression (r = 0.318, p = 0.007). Multiple regression analysis showed that VF progression was significantly associated with MCP-1 (odds ratio, OR = 1.021, 95% CI = 1.003-1.040; p = 0.020) and optic disc hemorrhage (ODH; OR = 1.573; 95% CI = 1.140-2.170; p = 0.023). CONCLUSIONS: Systemic MCP-1 levels were associated with VF progression in patients with NTG.
PURPOSE: To investigate the associations between endothelin-1 (ET-1) and macrophage chemoattractant protein-1 (MCP-1) levels and visual field (VF) progression in normal-tension glaucoma (NTG). METHODS: We conducted a prospective, longitudinal study in 71 patients with NTG. Blood samples from all subjects were assayed for ET-1 and MCP-1 concentrations, and baseline ophthalmic examinations, including the VF, were performed. Baseline data were compared with follow-up data over 3 years. RESULTS: After 3 years of follow-up, 14 of the 71 patients showed VF progression, and the systemic MCP-1 level was significantly associated with VF progression (r = 0.318, p = 0.007). Multiple regression analysis showed that VF progression was significantly associated with MCP-1 (odds ratio, OR = 1.021, 95% CI = 1.003-1.040; p = 0.020) and optic disc hemorrhage (ODH; OR = 1.573; 95% CI = 1.140-2.170; p = 0.023). CONCLUSIONS: Systemic MCP-1 levels were associated with VF progression in patients with NTG.
Entities:
Keywords:
Endothelin-1; macrophage chemoattractant protein-1; normal-tension glaucoma; progression; visual field
Authors: Jacob K Sterling; Modupe O Adetunji; Samyuktha Guttha; Albert R Bargoud; Katherine E Uyhazi; Ahmara G Ross; Joshua L Dunaief; Qi N Cui Journal: Cell Rep Date: 2020-11-03 Impact factor: 9.995