Literature DB >> 28305960

Fission yeast tmsl protein abrogates normal development in Xenopus laevis embryos.

Peter Wagner1, Michael Hoever2, Katrin Appel1, Walter Knöchel2, Mathias Montenarh1.   

Abstract

Recently we cloned tms1 (a putative dehydrogenase) by complementation of a human tumour-derived mutant p53 induced growth arrest in fission yeast. Microinjection of purified tmsl protein into Xenopus laevis embryos abrogated normal embryo development by causing cleavage retardation or cleavage arrest of injected blastomeres in a concentration dependant manner, whereas injection of specific affinity purified tms1 antiserum showed no significant morphological defects. Microinjection of tms1 protein together with affinity purified tms1 antibody resulted in a significantly reduced number of cleavage arrested embryos.

Entities:  

Keywords:  Xenopus laevis development; fission yeast; tms1

Year:  1995        PMID： 28305960     DOI： 10.1007/BF00241273

Source DB:  PubMed          Journal:  Rouxs Arch Dev Biol        ISSN： 0930-035X


  20 in total

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Authors:  C A Finlay; P W Hinds; A J Levine
Journal:  Cell       Date:  1989-06-30       Impact factor: 41.582

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Journal:  Nature       Date:  1992-07-02       Impact factor: 49.962

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Authors:  M Montenarh
Journal:  Int J Oncol       Date:  1992-06       Impact factor: 5.650

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Journal:  Nucleic Acids Res       Date:  1986-03-11       Impact factor: 16.971

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Authors:  D Wolf; S Admon; M Oren; V Rotter
Journal:  Mol Cell Biol       Date:  1984-03       Impact factor: 4.272

7.  A new 42-kda protein-binding to the growth suppressor protein-p53.

Authors:  K Appel; E Schneider; P Wagner; J Hoog; M Montenarh; C Karlsson
Journal:  Int J Oncol       Date:  1994-09       Impact factor: 5.650

8.  Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

Authors:  W E Mercer; M T Shields; M Amin; G J Sauve; E Appella; J W Romano; S J Ullrich
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

9.  Overexpression of wild-type p53 interferes with normal development in Xenopus laevis embryos.

Authors:  M Hoever; J H Clement; D Wedlich; M Montenarh; W Knöchel
Journal:  Oncogene       Date:  1994-01       Impact factor: 9.867

10.  Putative dehydrogenase tms1 suppresses growth arrest induced by a p53 tumour mutant in fission yeast.

Authors:  P Wagner; M Grimaldi; J R Jenkins
Journal:  Eur J Biochem       Date:  1993-10-15
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