Influence of indomethacin on lens regeneration in the newt notophthalmus viridescens.

Following lentectomy newts were injected with indomethacin in a variety of carrier solutions at doses ranging from 1.2-120 mg/kg body weight every other day for 15-17 days. The results show that injection of this drug according to the regimen used has no significant effect on regeneration of the lens. The data suggest, but do not prove, that prostaglandins may not play a major role in the early phases of lens regeneration in the newt.