BACKGROUND: Episodic memory disturbance is still considered as an exclusion criterion for behavioral variant frontotemporal dementia (bvFTD), but growing evidence suggests that memory can be impaired. OBJECTIVE: Our main purposes were to assess episodic memory in a group of bvFTD patients comparatively with Alzheimer's disease (AD) patients, and analyze the relationship between episodic memory and brain metabolism measured using positron emission tomography imaging with 18F-fluorodeoxyglucose (FDG-PET). METHODS: Twenty-six bvFTD, 29 AD, and 24 healthy controls were included. Episodic memory was assessed by the Free and Cued Selective Reminding Test (FCSRT), which controls for effective encoding and measures memory consolidation processing. All participants underwent FDG-PET brain scans to provide data for voxel-based brain mapping analysis. RESULTS: Half of bvFTD patients had a deficit of total, free delayed, and total free delayed recall as severe as AD patients (amnestic-FTD). The other half had FCSRT scores similar to controls (non-amnestic-FTD). Imaging analyses revealed that amnestic-FTD showed bilateral lower metabolism than non-amnestic-FTD in anterior parahippocampal and inferior temporal gyri. Additionally, FCSRT total and total delayed scores were inversely correlated with parahippocampal metabolism in both bvFTD and AD. Besides, bvFTD showed an inverse association among FCSRT and inferior temporal metabolism. CONCLUSIONS: Our findings support that bvFTD could present a genuine amnesia affecting storage and consolidation abilities, which involves structures implicated in the Papez circuit, as occurs in AD, and also inferior temporal regions. These results contribute to understanding the mechanisms underpinning memory dysfunction in bvFTD, and may be relevant to further revisions of the current diagnostic criteria.
BACKGROUND:Episodic memory disturbance is still considered as an exclusion criterion for behavioral variant frontotemporal dementia (bvFTD), but growing evidence suggests that memory can be impaired. OBJECTIVE: Our main purposes were to assess episodic memory in a group of bvFTD patients comparatively with Alzheimer's disease (AD) patients, and analyze the relationship between episodic memory and brain metabolism measured using positron emission tomography imaging with 18F-fluorodeoxyglucose (FDG-PET). METHODS: Twenty-six bvFTD, 29 AD, and 24 healthy controls were included. Episodic memory was assessed by the Free and Cued Selective Reminding Test (FCSRT), which controls for effective encoding and measures memory consolidation processing. All participants underwent FDG-PET brain scans to provide data for voxel-based brain mapping analysis. RESULTS: Half of bvFTD patients had a deficit of total, free delayed, and total free delayed recall as severe as ADpatients (amnestic-FTD). The other half had FCSRT scores similar to controls (non-amnestic-FTD). Imaging analyses revealed that amnestic-FTD showed bilateral lower metabolism than non-amnestic-FTD in anterior parahippocampal and inferior temporal gyri. Additionally, FCSRT total and total delayed scores were inversely correlated with parahippocampal metabolism in both bvFTD and AD. Besides, bvFTD showed an inverse association among FCSRT and inferior temporal metabolism. CONCLUSIONS: Our findings support that bvFTD could present a genuine amnesia affecting storage and consolidation abilities, which involves structures implicated in the Papez circuit, as occurs in AD, and also inferior temporal regions. These results contribute to understanding the mechanisms underpinning memory dysfunction in bvFTD, and may be relevant to further revisions of the current diagnostic criteria.
Authors: Aida Kamalian; Tina Khodadadifar; Amin Saberi; Maryam Masoudi; Julia A Camilleri; Claudia R Eickhoff; Mojtaba Zarei; Lorenzo Pasquini; Angela R Laird; Peter T Fox; Simon B Eickhoff; Masoud Tahmasian Journal: Alzheimers Dement (Amst) Date: 2022-05-29
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Authors: Jackie M Poos; Lucy L Russell; Georgia Peakman; Martina Bocchetta; Caroline V Greaves; Lize C Jiskoot; Emma L van der Ende; Harro Seelaar; Janne M Papma; Esther van den Berg; Yolande A L Pijnenburg; Barbara Borroni; Raquel Sanchez-Valle; Fermin Moreno; Robert Laforce; Caroline Graff; Matthias Synofzik; Daniela Galimberti; James B Rowe; Mario Masellis; Carmela Tartaglia; Elizabeth Finger; Rik Vandenberghe; Alexandre de Medonça; Fabrizio Tagliavini; Chris R Butler; Isabel Santana; Isabelle Le Ber; Alex Gerhard; Simon Ducharme; Johannes Levin; Adrian Danek; Markus Otto; Sandro Sorbi; Florence Pasquier; John C van Swieten; Jonathan D Rohrer Journal: Alzheimers Dement (Amst) Date: 2021-05-13
Authors: Eino Solje; Alberto Benussi; Emanuele Buratti; Anne M Remes; Annakaisa Haapasalo; Barbara Borroni Journal: Diagnostics (Basel) Date: 2021-04-27
Authors: Megan S Barker; Masood Manoochehri; Sandra J Rizer; Brian S Appleby; Danielle Brushaber; Sheena I Dev; Katrina L Devick; Bradford C Dickerson; Julie A Fields; Tatiana M Foroud; Leah K Forsberg; Douglas R Galasko; Nupur Ghoshal; Neill R Graff-Radford; Murray Grossman; Hilary W Heuer; Ging-Yuek Hsiung; John Kornak; Irene Litvan; Ian R Mackenzie; Mario F Mendez; Belen Pascual; Katherine P Rankin; Katya Rascovsky; Adam M Staffaroni; Maria Carmela Tartaglia; Sandra Weintraub; Bonnie Wong; Bradley F Boeve; Adam L Boxer; Howard J Rosen; Jill Goldman; Edward D Huey; Stephanie Cosentino Journal: Cortex Date: 2021-03-19 Impact factor: 4.644
Authors: Josefa Díaz-Álvarez; Jordi A Matias-Guiu; María Nieves Cabrera-Martín; Vanesa Pytel; Ignacio Segovia-Ríos; Fernando García-Gutiérrez; Laura Hernández-Lorenzo; Jorge Matias-Guiu; José Luis Carreras; José L Ayala Journal: Front Aging Neurosci Date: 2022-02-03 Impact factor: 5.750
Authors: Fernando García-Gutierrez; Josefa Díaz-Álvarez; Jordi A Matias-Guiu; Vanesa Pytel; Jorge Matías-Guiu; María Nieves Cabrera-Martín; José L Ayala Journal: Med Biol Eng Comput Date: 2022-07-19 Impact factor: 3.079