| Literature DB >> 28302401 |
Jianbin Wang1, Kehui Xie1, Hongquan Duan2, Yi Wang1, He Ma3, Hongzheng Fu4.
Abstract
Five new diterpenoid glycosides, siegesides A-E (1-5), along with the known compound darutoside (6) were isolated and characterized from the ethanol extract of Siegesbeckia pubescens. The structural elucidation of the isolates was accomplished by extensive HRESIMS and NMR analysis. Compounds 1 and 2 are epimers of 6. All isolates were evaluated for their inhibition on the migration of MB-MDA-231 breast cancer cells induced by the chemokine epithelial growth factor, and compound 2 showed superior inhibitory activities in comparison with the positive control drug with IC50 value of 0.27μM.Entities:
Keywords: Chemokine epithelial growth factor; Diterpenoid glycosides; MB-MDA-231 breast cancer cells; Siegesbeckia pubescens
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Year: 2017 PMID： 28302401 DOI： 10.1016/j.bmcl.2017.02.051
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823