Bishal Marasini 1 , Ravi P Sahu 2 Show Affiliations »
Abstract
BACKGROUND & OBJECTIVE: Pancreatic cancer is one of the most lethal malignancies accounting for the fourth leading cause of cancer-related deaths in the United States. Among several explored anticancer agents, Gemcitabine, a nucleoside analogue remained a front line chemotherapeutic agent for the treatment of pancreatic cancer. However, gemcitabine exerts a low response rate with limited progression free survival in patients due to cellular resistance of pancreatic tumors to this therapy. Several chemotherapeutic agents have been explored in combination with gemcitabine against pancreatic cancer with overall mixed responses and survival rates. Naturally occurring dietary agents possess promising anticancer properties and have been shown to target various oncogenic signaling pathways in in-vitro and in-vivo pancreatic cancer models. RESULTS: Multiple studies using natural compounds have shown increased therapeutic efficacy of gemcitabine in pancreatic cancer models. CONCLUSION: This review is focused on recent updates on cellular, preclinical and clinical studies utilizing natural anticancer agents with gemcitabine against pancreatic cancer. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND & ; OBJECTIVE: Pancreatic cancer is one of the most lethal malignancies accounting for the fourth leading cause of cancer -related deaths in the United States. Among several explored anticancer agents, Gemcitabine , a nucleoside analogue remained a front line chemotherapeutic agent for the treatment of pancreatic cancer . However, gemcitabine exerts a low response rate with limited progression free survival in patients due to cellular resistance of pancreatic tumors to this therapy. Several chemotherapeutic agents have been explored in combination with gemcitabine against pancreatic cancer with overall mixed responses and survival rates. Naturally occurring dietary agents possess promising anticancer properties and have been shown to target various oncogenic signaling pathways in in-vitro and in-vivo pancreatic cancer models. RESULTS: Multiple studies using natural compounds have shown increased therapeutic efficacy of gemcitabine in pancreatic cancer models. CONCLUSION: This review is focused on recent updates on cellular, preclinical and clinical studies utilizing natural anticancer agents with gemcitabine against pancreatic cancer . Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Chemical
Disease
Species
Keywords:
Combination therapy for pancreatic cancer; diabetes; gemcitabine; jaundice; natural anti-cancer agents; pancreaticzzm321990cancer
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Year: 2017
PMID： 28302042 DOI： 10.2174/1389557517666170315124438
Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862