Literature DB >> 28302040

Trypanothione Reductase: A Target for the Development of Anti- Trypanosoma cruzi Drugs.

Karina Vázquez1, Margot Paulino2, Cristian O Salas3, Juan J Zarate-Ramos1, Brenda Vera2, Gildardo Rivera4.   

Abstract

BACKGROUND &
OBJECTIVE: Chagas disease or American trypanosomiasis is a major parasitic disease in Latin America with restricted available treatment: nifurtimox and benznidazole. These two drugs are ineffective in the chronic phase of the disease; therefore, there is a need for the development of new, efficient and safe drugs for the treatment of this pathology. With this goal, one of the promising targets is trypanothione reductase (TR), a key enzyme in the metabolism of Trypanosoma cruzi.
CONCLUSION: In this review, we analyse the importance of TR as a drug target, as well as the well-known and new inhibitors reported in the last decade as potential therapeutic agents for Chagas disease. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Chagas disease; Trypanosoma cruzi; drugs; inhibitors; target; trypanothione reductase

Mesh：

Substances：

Year:  2017        PMID： 28302040     DOI： 10.2174/1389557517666170315145410

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  8 in total

1.  Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme.

Authors:  Lorenzo Turcano; Theo Battista; Esther Torrente De Haro; Antonino Missineo; Cristina Alli; Giacomo Paonessa; Gianni Colotti; Steven Harper; Annarita Fiorillo; Andrea Ilari; Alberto Bresciani
Journal:  PLoS Negl Trop Dis       Date:  2020-05-21

2.  Relevance of Trypanothione Reductase Inhibitors on Trypanosoma cruzi Infection: A Systematic Review, Meta-Analysis, and In Silico Integrated Approach.

Authors:  Andréa Aparecida Santos Mendonça; Camila Morais Coelho; Marcia Paranho Veloso; Ivo Santana Caldas; Reggiani Vilela Gonçalves; Antônio Lucio Teixeira; Aline Silva de Miranda; Rômulo Dias Novaes
Journal:  Oxid Med Cell Longev       Date:  2018-10-24       Impact factor: 6.543

3.  Leishmania mexicana Trypanothione Reductase Inhibitors: Computational and Biological Studies.

Authors:  Félix Matadamas-Martínez; Alicia Hernández-Campos; Alfredo Téllez-Valencia; Alejandra Vázquez-Raygoza; Sandra Comparán-Alarcón; Lilián Yépez-Mulia; Rafael Castillo
Journal:  Molecules       Date:  2019-09-04       Impact factor: 4.411

4.  In Vitro, In Vivo, and In Silico Studies of Cumanin Diacetate as a Potential Drug against Trypanosoma cruzi Infection.

Authors:  Andrés Sánchez Alberti; María F Beer; Natacha Cerny; Augusto E Bivona; Lucas Fabian; Celina Morales; Albertina Moglioni; Emilio L Malchiodi; Osvaldo J Donadel; Valeria P Sülsen
Journal:  ACS Omega       Date:  2021-12-20

5.  New Amino Naphthoquinone Derivatives as Anti-Trypanosoma cruzi Agents Targeting Trypanothione Reductase.

Authors:  Christian Espinosa-Bustos; Mariana Ortiz Pérez; Alonzo Gonzalez-Gonzalez; Ana María Zarate; Gildardo Rivera; Javier A Belmont-Díaz; Emma Saavedra; Mauricio A Cuellar; Karina Vázquez; Cristian O Salas
Journal:  Pharmaceutics       Date:  2022-05-25       Impact factor: 6.525

Review 6.  Current Treatments to Control African Trypanosomiasis and One Health Perspective.

Authors:  Alberto Venturelli; Lorenzo Tagliazucchi; Clara Lima; Federica Venuti; Giulia Malpezzi; George E Magoulas; Nuno Santarem; Theodora Calogeropoulou; Anabela Cordeiro-da-Silva; Maria Paola Costi
Journal:  Microorganisms       Date:  2022-06-27

7.  Computational Drug Repositioning for Chagas Disease Using Protein-Ligand Interaction Profiling.

Authors:  Alfredo Juárez-Saldivar; Michael Schroeder; Sebastian Salentin; V Joachim Haupt; Emma Saavedra; Citlali Vázquez; Francisco Reyes-Espinosa; Verónica Herrera-Mayorga; Juan Carlos Villalobos-Rocha; Carlos A García-Pérez; Nuria E Campillo; Gildardo Rivera
Journal:  Int J Mol Sci       Date:  2020-06-16       Impact factor: 5.923

Review 8.  Screening Marine Natural Products for New Drug Leads against Trypanosomatids and Malaria.

Authors:  María Álvarez-Bardón; Yolanda Pérez-Pertejo; César Ordóñez; Daniel Sepúlveda-Crespo; Nestor M Carballeira; Babu L Tekwani; Sankaranarayanan Murugesan; Maria Martinez-Valladares; Carlos García-Estrada; Rosa M Reguera; Rafael Balaña-Fouce
Journal:  Mar Drugs       Date:  2020-03-31       Impact factor: 5.118
  8 in total

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