Literature DB >> 28301306

Two possible modes of pioneering associated with combinations of H2A.Z and p300/CBP at nucleosome-occupied enhancers.

Pierre Cauchy1, Frederic Koch2, Jean-Christophe Andrau3.   

Abstract

Pioneer transcription factors are defined by their ability to bind nucleosome-occupied regions. Here, we discuss the properties of nucleosomes bound by pioneers at enhancer regions. We describe how select pioneers bind nucleosome-occupied or -depleted enhancer sites. Importantly, by revisiting and expanding existing data sets, we show differential H2A.Z and p300/CBP association at bound enhancers, highlighting two possible pioneering modes.

Entities:  

Keywords:  H2A.Z; MNase-Seq; labile; nucleosome; p300/CBP; transcription factor

Mesh:

Substances:

Year:  2017        PMID: 28301306      PMCID: PMC5501375          DOI: 10.1080/21541264.2017.1291395

Source DB:  PubMed          Journal:  Transcription        ISSN: 2154-1272


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