| Literature DB >> 28301306 |
Pierre Cauchy1, Frederic Koch2, Jean-Christophe Andrau3.
Abstract
Pioneer transcription factors are defined by their ability to bind nucleosome-occupied regions. Here, we discuss the properties of nucleosomes bound by pioneers at enhancer regions. We describe how select pioneers bind nucleosome-occupied or -depleted enhancer sites. Importantly, by revisiting and expanding existing data sets, we show differential H2A.Z and p300/CBP association at bound enhancers, highlighting two possible pioneering modes.Entities:
Keywords: H2A.Z; MNase-Seq; labile; nucleosome; p300/CBP; transcription factor
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Year: 2017 PMID: 28301306 PMCID: PMC5501375 DOI: 10.1080/21541264.2017.1291395
Source DB: PubMed Journal: Transcription ISSN: 2154-1272