| Literature DB >> 28300700 |
Wei Zhang1, Sheng-Yuan Zhang2, Gui-Yang Wang3, Ni-Ping Li3, Min-Feng Chen3, Ji-Hong Gu3, Dong-Mei Zhang4, Lei Wang5, Wen-Cai Ye6.
Abstract
Five new koumine-type alkaloids (1-5) along with six known ones were isolated from the roots of Gelsemium elegans. Their structures with absolute configurations were elucidated on the basis of NMR spectroscopy and electronic circular dichroism spectral analyses. The inhibitory effects of compounds 1-11 on the viability of three tumor cell lines (A-649, HepG2, and HuH7) were evaluated by the MTT assay.Entities:
Keywords: Cytotoxic activity; Gelsemium elegans; Koumine-type alkaloids
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Year: 2017 PMID： 28300700 DOI： 10.1016/j.fitote.2017.03.004
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882