Nirav D Raichura1, Md Shahid Alam1, Veena Olma Noronha2, Bipasha Mukherjee3. 1. Department of Oculoplasty, Orbit, Reconstructive and Aesthetic Services, Sankara Nethralaya, Medical Research Foundation, Tamil Nadu, India. 2. VRR Scans, Tamil Nadu, India. 3. Department of Oculoplasty, Orbit, Reconstructive and Aesthetic Services, Sankara Nethralaya, Medical Research Foundation, Tamil Nadu, India. Electronic address: beas003@yahoo.co.uk.
Abstract
PURPOSE: To evaluate the efficacy of intralesional bleomycin injection in the management of lymphangiomas of the orbit. METHODS: This prospective noncomparative interventional case study included 13 patients with orbital lymphangiomas. Reconstituted bleomycin 1-5 ml (0.5 IU/kg body weight; maximum, 15 IU/ml) was injected with 2% lignocaine in the lesion as seen on imaging or, in deeper lesions, under ultrasound guidance. Repeat injections were administered when required after every 4 weeks. The decision to retreat was based on clinical and radiological evidence of response. RESULTS: Patients were treated with 1-6 injections of bleomycin 0.5 IU/kg body weight. Dramatic response was achieved in all cases. During the mean follow-up period of 19.69 months (range, 7-26 months) none of the patients experienced recurrence or significant complication. CONCLUSIONS: In this patient cohort lymphangiomas of the orbit showed favorable and promising results with intralesional injections of bleomycin. This treatment should be considered as a first-line therapy for lymphangiomas of the orbit.
PURPOSE: To evaluate the efficacy of intralesional bleomycin injection in the management of lymphangiomas of the orbit. METHODS: This prospective noncomparative interventional case study included 13 patients with orbital lymphangiomas. Reconstituted bleomycin 1-5 ml (0.5 IU/kg body weight; maximum, 15 IU/ml) was injected with 2% lignocaine in the lesion as seen on imaging or, in deeper lesions, under ultrasound guidance. Repeat injections were administered when required after every 4 weeks. The decision to retreat was based on clinical and radiological evidence of response. RESULTS:Patients were treated with 1-6 injections of bleomycin 0.5 IU/kg body weight. Dramatic response was achieved in all cases. During the mean follow-up period of 19.69 months (range, 7-26 months) none of the patients experienced recurrence or significant complication. CONCLUSIONS: In this patient cohort lymphangiomas of the orbit showed favorable and promising results with intralesional injections of bleomycin. This treatment should be considered as a first-line therapy for lymphangiomas of the orbit.