Bernardo Dell'Osso1, Beatrice Benatti1, Chiara Arici1, Carlotta Palazzo1, A Carlo Altamura1, Eric Hollander2, Naomi Fineberg3, Dan J Stein4, Humberto Nicolini5, Nuria Lanzagorta6, Donatella Marazziti7, Stefano Pallanti8, Michael van Ameringen9, Christine Lochner10, Oguz Karamustafalioglu11, Luchezar Hranov12, Martijn Figee13, Lynne Drummond14, Carolyn I Rodriguez15, John Grant16, Damiaan Denys13, Jose M Menchon17, Joseph Zohar18. 1. 1Department of Psychiatry,University of Milan,Fondazione IRCCS Ca'Granda,Ospedale Maggiore Policlinico,Milano,Italy. 2. 3Department of Psychiatry and Behavioral Sciences,Albert Einstein College of Medicine and Montefiore Medical Center,New York,New York,USA. 3. 4Mental Health Unit,Hertfordshire Partnership Foundation Trust,Queen Elizabeth II Hospital,Welwyn Garden City,United Kingdom. 4. 5MRC Unit on Anxiety and Stress Disorders,Department of Psychiatry and Mental Health,University of Cape Town,Cape Town,South Africa. 5. 6Genomics of Psychiatric and Neurodegenerative Diseases Laboratory, National Institute of Genomic Medicine (INMEGEN),Mexico City,Mexico. 6. 7Carracci Medical Group,Mexico City,Mexico. 7. 8Dipartimento di Psichiatria,Neurobiologia,Farmacologia e Biotechnologie,Università di Pisa,Italy. 8. 9Department of Psychiatry,University of Florence,and Institute of Neurosciences,Florence,Italy. 9. 10Department of Psychiatry and Behavioural Neurosciences,McMaster University,Hamilton,Ontario,Canada. 10. 11MRC Unit on Anxiety and Stress Disorders,Department of Psychiatry,University of Stellenbosch,South Africa. 11. 12Department of Psychiatry,Sisli Eftal Teaching and Research Hospital,Istanbul,Turkey. 12. 13University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry Sveti Naum,Sofia,Bulgaria. 13. 14Department of Psychiatry,Academic Medical Center,University of Amsterdam,Amsterdam,The Netherlands. 14. 15National and Trustwide Services for OCD/BDD,SW London and St. George's,National Health Service Trust,London,United Kingdom. 15. 2Department of Psychiatry and Behavioral Sciences,Stanford University,Stanford,California,USA. 16. 16Department of Psychiatry and Behavioral Neuroscience,University of Chicago,Illinois,USA. 17. 17Psychiatry Unit at the Hospital Universitari de Bellvitge-IDIBELL,University of Barcelona, Cibersam,Barcelona,Spain. 18. 18Tel Aviv University, Sackler School of Medicine, Israel Post-Trauma Center, Research Foundation by the Sheba Medical Center,Israel.
Abstract
OBJECTIVE: Obsessive-compulsive disorder (OCD) is associated with variable risk of suicide and prevalence of suicide attempt (SA). The present study aimed to assess the prevalence of SA and associated sociodemographic and clinical features in a large international sample of OCD patients. METHODS: A total of 425 OCD outpatients, recruited through the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) network, were assessed and categorized in groups with or without a history of SA, and their sociodemographic and clinical features compared through Pearson's chi-squared and t tests. Logistic regression was performed to assess the impact of the collected data on the SA variable. RESULTS: 14.6% of our sample reported at least one SA during their lifetime. Patients with an SA had significantly higher rates of comorbid psychiatric disorders (60 vs. 17%, p<0.001; particularly tic disorder), medical disorders (51 vs. 15%, p<0.001), and previous hospitalizations (62 vs. 11%, p<0.001) than patients with no history of SA. With respect to geographical differences, European and South African patients showed significantly higher rates of SA history (40 and 39%, respectively) compared to North American and Middle-Eastern individuals (13 and 8%, respectively) (χ2=11.4, p<0.001). The logistic regression did not show any statistically significant predictor of SA among selected independent variables. CONCLUSIONS: Our international study found a history of SA prevalence of ~15% in OCD patients, with higher rates of psychiatric and medical comorbidities and previous hospitalizations in patients with a previous SA. Along with potential geographical influences, the presence of the abovementioned features should recommend additional caution in the assessment of suicide risk in OCD patients.
OBJECTIVE:Obsessive-compulsive disorder (OCD) is associated with variable risk of suicide and prevalence of suicide attempt (SA). The present study aimed to assess the prevalence of SA and associated sociodemographic and clinical features in a large international sample of OCDpatients. METHODS: A total of 425 OCD outpatients, recruited through the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) network, were assessed and categorized in groups with or without a history of SA, and their sociodemographic and clinical features compared through Pearson's chi-squared and t tests. Logistic regression was performed to assess the impact of the collected data on the SA variable. RESULTS: 14.6% of our sample reported at least one SA during their lifetime. Patients with an SA had significantly higher rates of comorbid psychiatric disorders (60 vs. 17%, p<0.001; particularly tic disorder), medical disorders (51 vs. 15%, p<0.001), and previous hospitalizations (62 vs. 11%, p<0.001) than patients with no history of SA. With respect to geographical differences, European and South African patients showed significantly higher rates of SA history (40 and 39%, respectively) compared to North American and Middle-Eastern individuals (13 and 8%, respectively) (χ2=11.4, p<0.001). The logistic regression did not show any statistically significant predictor of SA among selected independent variables. CONCLUSIONS: Our international study found a history of SA prevalence of ~15% in OCDpatients, with higher rates of psychiatric and medical comorbidities and previous hospitalizations in patients with a previous SA. Along with potential geographical influences, the presence of the abovementioned features should recommend additional caution in the assessment of suicide risk in OCDpatients.
Authors: Lily A Brown; Emily Wakschal; Stefanie Russman-Block; Christina L Boisseau; Maria C Mancebo; Jane L Eisen; Steven A Rasmussen Journal: J Affect Disord Date: 2018-11-13 Impact factor: 4.839
Authors: Vahid Khosravani; Seyed Mehdi Samimi Ardestani; Farangis Sharifi Bastan; Dean McKay; Gordon J G Asmundson Journal: Clin Psychol Psychother Date: 2021-05-05
Authors: Anna Sidorchuk; Ralf Kuja-Halkola; Bo Runeson; Paul Lichtenstein; Henrik Larsson; Christian Rück; Brian M D'Onofrio; David Mataix-Cols; Lorena Fernández de la Cruz Journal: Mol Psychiatry Date: 2019-04-08 Impact factor: 15.992