| Literature DB >> 28299745 |
Fernando Luiz Affonso Fonseca1,2, Beatriz da Costa Aguiar Alves3, Ligia Ajaime Azzalis4, Thaís Moura Gáscon Belardo3.
Abstract
Matrix metalloprotease play a vital role in many cellular processes. Dysfunction in activity of these enzymes has been implicated in the pathogenesis of a number of diseases. Factors that affect the balanced interaction between MMPs and their inhibitors, such as genetic mutations of extracellular matrix components or dysregulation of MMP expression, can lead to various diseases. Due to their essential role in ECM remodeling, MMPs have become targets of interest as biomarkers for the diagnosis and prognosis of diseases associated with alterations of the ECM.Entities:
Keywords: Cancer; Disease; Inflammatory disease; Matrix metalloproteases
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Year: 2017 PMID： 28299745 DOI： 10.1007/978-1-4939-6863-3_17
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745