Literature DB >> 28299650

The Role of Runx1 in Embryonic Blood Cell Formation.

Amanda D Yzaguirre1, Marella F T R de Bruijn2, Nancy A Speck3.   

Abstract

The de novo generation of hematopoietic stem and progenitor cells (HSPC) occurs solely during embryogenesis from a population of epithelial cells called hemogenic endothelium (HE). During midgestation HE cells in multiple intra- and extraembryonic vascular beds leave the vessel wall as they transition into HSPCs in a process termed the endothelial to hematopoietic transition (EHT). Runx1 expression in HE cells orchestrates the transcriptional switch necessary for the transdifferentiation of endothelial cells into functional HSPCs. Runx1 is widely considered the master regulator of developmental hematopoiesis because it plays an essential function during specification of the hematopoietic lineage during embryogenesis. Here we review the role of Runx1 in embryonic HSPC formation, with a particular focus on its role in hemogenic endothelium.

Entities:  

Keywords:  Hematopoiesis; Hematopoietic stem cell; Hemogenic endothelium; Runx1

Mesh：

Substances：

Year:  2017        PMID： 28299650      PMCID： PMC5813695          DOI： 10.1007/978-981-10-3233-2_4

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  130 in total

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Authors:  K Sasaki; H Yagi; R T Bronson; K Tominaga; T Matsunashi; K Deguchi; Y Tani; T Kishimoto; T Komori
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9.  Development of hematopoietic stem cell activity in the mouse embryo.

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