| Literature DB >> 28299649 |
Ezra Blumenthal1, Sarah Greenblatt1, Guang Huang2, Koji Ando1, Ye Xu1,3, Stephen D Nimer4,5.
Abstract
The RUNX family of transcription factors plays important roles in tissue-specific gene expression. Many of their functions depend on specific post-translational modifications (PTMs), and in this review, we describe how PTMs govern RUNX DNA binding, transcriptional activity, protein stability, cellular localization, and protein-protein interactions. We also report how these processes can be disrupted in disease settings. Finally, we describe how alterations of RUNX1, or the enzymes that catalyze its post-translational modifications, contribute to hematopoietic malignancies.Entities:
Keywords: Acetylation; Acute Myeloid Leukemia; CBFβ; Cleidocranial Dysplasia; FPD/AML; Methylation; Phosphorylation; Post-Translational Modifications; RUNX1; RUNX2; RUNX3; Transcriptional Activation; Transcriptional Repression; Ubiquitylation
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Year: 2017 PMID： 28299649 DOI： 10.1007/978-981-10-3233-2_3
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622