Marcello Ricardo Paulista Markus1, Nicole Werner2, Sabine Schipf2, Ulrike Siewert-Markus2, Martin Bahls2, Sebastian Edgar Baumeister2, Henry Völzke2, Stephan Burkhard Felix2, Till Ittermann2, Marcus Dörr2. 1. From the Department of Internal Medicine B (M.R.P.M., M.B., S.B.F., M.D.) and Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine (M.R.P.M., N.A., S.S., S.E.B., H.V., T.I.), University Medicine Greifswald, Germany; DZHK (German Centre for Cardiovascular Research) (M.R.P.M., M.B., H.V., S.B.F., T.I., M.D.) and DZD (German Center for Diabetes Research) (M.R.P.M., S.S., H.V., T.I.), partner site Greifswald, Germany; Institut für Psychologie, Ernst-Moritz-Arndt-Universität Greifswald, Germany (U.S.-M.); and Department of Epidemiology and Preventive Medicine, University of Regensburg, Germany (S.E.B.). marcello.markus@uni-greifswald.de. 2. From the Department of Internal Medicine B (M.R.P.M., M.B., S.B.F., M.D.) and Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine (M.R.P.M., N.A., S.S., S.E.B., H.V., T.I.), University Medicine Greifswald, Germany; DZHK (German Centre for Cardiovascular Research) (M.R.P.M., M.B., H.V., S.B.F., T.I., M.D.) and DZD (German Center for Diabetes Research) (M.R.P.M., S.S., H.V., T.I.), partner site Greifswald, Germany; Institut für Psychologie, Ernst-Moritz-Arndt-Universität Greifswald, Germany (U.S.-M.); and Department of Epidemiology and Preventive Medicine, University of Regensburg, Germany (S.E.B.).
Abstract
BACKGROUND: The different effects of total body weight (TBW), fat-free mass (FFM), and fat mass (FM) on left ventricular (LV) geometry and function are complex. We investigated the associations of changes over time in TBW, FM, and FFM with changes in LV geometry and function. METHODS AND RESULTS: We analyzed data from 1189 subjects (694 women), aged 44 to 86 years, from the baseline and the 5-year follow-up examination of the population-based SHIP (Study of Health in Pomerania). TBW was measured, and FFM and FM were calculated based on height-weight models derived from bioelectrical impedance studies. Echocardiographic measurements of LV geometry and function were performed according to the guidelines of the American Society of Echocardiography. Changes in body composition measures were associated with changes in LV geometry and function by multivariable-adjusted linear regression models. A 1-kg increase/decrease in TBW or FM was associated, respectively, with an increase/decrease of 0.89 g or 1.84 g in LV mass, whereas there was no such association on changes in FFM. Moreover, an increase in FM was associated with LV concentric remodeling and impairment of systolic and diastolic function parameters, whereas an increase in FFM was associated with LV eccentric remodeling and improved systolic and diastolic functional variables. CONCLUSIONS: Our findings indicate that changes in LV morphology and function depend on the type of body mass composition. Prospective data need to address whether specific changes in body composition over time may affect the risk for heart dysfunction more precisely than the change in TBW.
BACKGROUND: The different effects of total body weight (TBW), fat-free mass (FFM), and fat mass (FM) on left ventricular (LV) geometry and function are complex. We investigated the associations of changes over time in TBW, FM, and FFM with changes in LV geometry and function. METHODS AND RESULTS: We analyzed data from 1189 subjects (694 women), aged 44 to 86 years, from the baseline and the 5-year follow-up examination of the population-based SHIP (Study of Health in Pomerania). TBW was measured, and FFM and FM were calculated based on height-weight models derived from bioelectrical impedance studies. Echocardiographic measurements of LV geometry and function were performed according to the guidelines of the American Society of Echocardiography. Changes in body composition measures were associated with changes in LV geometry and function by multivariable-adjusted linear regression models. A 1-kg increase/decrease in TBW or FM was associated, respectively, with an increase/decrease of 0.89 g or 1.84 g in LV mass, whereas there was no such association on changes in FFM. Moreover, an increase in FM was associated with LV concentric remodeling and impairment of systolic and diastolic function parameters, whereas an increase in FFM was associated with LV eccentric remodeling and improved systolic and diastolic functional variables. CONCLUSIONS: Our findings indicate that changes in LV morphology and function depend on the type of body mass composition. Prospective data need to address whether specific changes in body composition over time may affect the risk for heart dysfunction more precisely than the change in TBW.
Authors: Jon Edqvist; Araz Rawshani; Martin Adiels; Lena Björck; Marcus Lind; Ann-Marie Svensson; Sofia Gudbjörnsdottir; Naveed Sattar; Annika Rosengren Journal: J Am Heart Assoc Date: 2019-12-10 Impact factor: 5.501
Authors: Alan C Kwan; Gerran Salto; Emmanuella Demosthenes; Birgitta T Lehman; Ewa Osypiuk; Plamen Stantchev; Ramachandran S Vasan; Susan Cheng Journal: MethodsX Date: 2020-11-26
Authors: Stefan Frenzel; Katharina Wittfeld; Robin Bülow; Henry Völzke; Nele Friedrich; Mohamad Habes; Stephan B Felix; Marcus Dörr; Hans J Grabe; Martin Bahls Journal: J Am Heart Assoc Date: 2021-09-01 Impact factor: 5.501