Literature DB >> 28297568

Safety Studies for Use of Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells in a Rabbit Model for Osteoarthritis to Support a Phase I Clinical Trial.

Scott M Riester1, Janet M Denbeigh1, Yang Lin1,2, Dakota L Jones1,3, Tristan de Mooij1, Eric A Lewallen1, Hai Nie1, Christopher R Paradise1, Darcie J Radel4, Amel Dudakovic1, Emily T Camilleri1, Dirk R Larson5, Wenchun Qu6,7, Aaron J Krych1, Matthew A Frick8, Hee-Jeong Im9,10,11,12, Allan B Dietz4, Jay Smith6,8,13, Andre J van Wijnen1,3,14.   

Abstract

Adipose-derived mesenchymal stem cells (AMSCs) offer potential as a therapeutic option for clinical applications in musculoskeletal regenerative medicine because of their immunomodulatory functions and capacity for trilineage differentiation. In preparation for a phase I clinical trial using AMSCs to treat patients with osteoarthritis, we carried out preclinical studies to assess the safety of human AMSCs within the intra-articular joint space. Culture-expanded human AMSCs grown in human platelet-lysate were delivered via intra-articular injections into normal healthy rabbit knees and knees at risk for the development of osteoarthritis after bilateral medial anterior hemimeniscectomy. Treatment outcomes and safety were evaluated by assessing the general health, function, and behavior of the animals. Joint tissues were analyzed by x-ray, magnetic resonance imaging, and histopathology. Intra-articular AMSC therapy was well tolerated in this study. We did not observe adverse systemic reactions, nor did we find evidence of damage to intra-articular joint tissues. Thus, the data generated in this study show a favorable safety profile for AMSCs within the joint space in support of a phase I clinical trial evaluating the clinical utility of AMSCs to treat osteoarthritis. Stem Cells Translational Medicine 2017;6:910-922.
© 2016 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.

Entities:  

Keywords:  Cell therapy; Osteoarthritis; Rabbit; Regenerative medicine; Stem cell; Transplant

Mesh：

Year:  2016        PMID： 28297568      PMCID： PMC5442773          DOI： 10.5966/sctm.2016-0097

Source DB:  PubMed          Journal:  Stem Cells Transl Med        ISSN： 2157-6564            Impact factor:   6.940


  63 in total

1.  Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomised controlled trial.

Authors:  Michael E Farkouh; Howard Kirshner; Robert A Harrington; Sean Ruland; Freek W A Verheugt; Thomas J Schnitzer; Gerd R Burmester; Eduardo Mysler; Marc C Hochberg; Michael Doherty; Elena Ehrsam; Xavier Gitton; Gerhard Krammer; Bernhard Mellein; Alberto Gimona; Patrice Matchaba; Christopher J Hawkey; James H Chesebro
Journal:  Lancet       Date:  2004 Aug 21-27       Impact factor: 79.321

Review 2.  Cartilage MRI T2 relaxation time mapping: overview and applications.

Authors:  Timothy J Mosher; Bernard J Dardzinski
Journal:  Semin Musculoskelet Radiol       Date:  2004-12       Impact factor: 1.777

3.  Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis.

Authors:  Menno ter Huurne; Rik Schelbergen; Roxane Blattes; Arjen Blom; Wouter de Munter; Lilyanne C Grevers; Jannik Jeanson; Danièle Noël; Louis Casteilla; Christian Jorgensen; Wim van den Berg; Peter L E M van Lent
Journal:  Arthritis Rheum       Date:  2012-11

4.  A new model of osteoarthritis in rabbits. I. Development of knee joint pathology following lateral meniscectomy and section of the fibular collateral and sesamoid ligaments.

Authors:  C Colombo; M Butler; E O'Byrne; L Hickman; D Swartzendruber; M Selwyn; B Steinetz
Journal:  Arthritis Rheum       Date:  1983-07

5.  Intra-articular administration of xenogeneic neonatal Mesenchymal Stromal Cells early after meniscal injury down-regulates metalloproteinase gene expression in synovium and prevents cartilage degradation in a rabbit model of osteoarthritis.

Authors:  N Saulnier; E Viguier; E Perrier-Groult; C Chenu; E Pillet; T Roger; S Maddens; C Boulocher
Journal:  Osteoarthritis Cartilage       Date:  2014-09-16       Impact factor: 6.576

6.  Long-term detection of human adipose-derived mesenchymal stem cells after intraarticular injection in SCID mice.

Authors:  Karine Toupet; Marie Maumus; Julie-Anne Peyrafitte; Philippe Bourin; Peter L E M van Lent; Rosanna Ferreira; Béatrice Orsetti; Nelly Pirot; Louis Casteilla; Christian Jorgensen; Danièle Noël
Journal:  Arthritis Rheum       Date:  2013-07

7.  Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT).

Authors:  Philippe Bourin; Bruce A Bunnell; Louis Casteilla; Massimo Dominici; Adam J Katz; Keith L March; Heinz Redl; J Peter Rubin; Kotaro Yoshimura; Jeffrey M Gimble
Journal:  Cytotherapy       Date:  2013-04-06       Impact factor: 5.414

8.  Intra-articular delivery of liposomal celecoxib-hyaluronate combination for the treatment of osteoarthritis in rabbit model.

Authors:  Ji Dong; Dinghua Jiang; Zhen Wang; Guizhong Wu; Liyan Miao; Lixin Huang
Journal:  Int J Pharm       Date:  2012-11-27       Impact factor: 5.875

9.  Repair of the Complete Radial Tear of the Anterior Horn of the Medial Meniscus in Rabbits: A Comparison between Simple Pullout Repair and Pullout Repair with Human Bone Marrow Stem Cell Implantation.

Authors:  Jang-Hee Hong; Jong-Il Park; Kyung-Hee Kim; Young-Mo Kim; Yong-Bum Joo; Yoo-Sun Jeon
Journal:  Knee Surg Relat Res       Date:  2011-09-26

10.  The role of stem cells in osteoarthritis: An experimental study in rabbits.

Authors:  A Singh; S C Goel; K K Gupta; M Kumar; G R Arun; H Patil; V Kumaraswamy; S Jha
Journal:  Bone Joint Res       Date:  2014-02-13       Impact factor: 5.853
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  10 in total

Review 1.  The potential role of adult stem cells in the management of the rheumatic diseases.

Authors:  Tiziana Franceschetti; Cosimo De Bari
Journal:  Ther Adv Musculoskelet Dis       Date:  2017-04-20       Impact factor: 5.346

2.  Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development.

Authors:  Emily T Camilleri; Amel Dudakovic; Scott M Riester; Catalina Galeano-Garces; Christopher R Paradise; Elizabeth W Bradley; Meghan E McGee-Lawrence; Hee-Jeong Im; Marcel Karperien; Aaron J Krych; Jennifer J Westendorf; A Noelle Larson; Andre J van Wijnen
Journal:  J Biol Chem       Date:  2018-10-16       Impact factor: 5.157

3.  Profiling of human epigenetic regulators using a semi-automated real-time qPCR platform validated by next generation sequencing.

Authors:  Amel Dudakovic; Martina Gluscevic; Christopher R Paradise; Halil Dudakovic; Farzaneh Khani; Roman Thaler; Farah S Ahmed; Xiaodong Li; Allan B Dietz; Gary S Stein; Martin A Montecino; David R Deyle; Jennifer J Westendorf; Andre J van Wijnen
Journal:  Gene       Date:  2017-01-27       Impact factor: 3.688

4.  Effect of Lidocaine on Viability and Gene Expression of Human Adipose-derived Mesenchymal Stem Cells: An in vitro Study.

Authors:  Hai Nie; Eva Kubrova; Tao Wu; Janet M Denbeigh; Christine Hunt; Allan B Dietz; Jay Smith; Wenchun Qu; Andre J van Wijnen
Journal:  PM R       Date:  2019-05-30       Impact factor: 2.298

Review 5.  Cell-based therapies have disease-modifying effects on osteoarthritis in animal models. A systematic review by the ESSKA Orthobiologic Initiative. Part 1: adipose tissue-derived cell-based injectable therapies.

Authors:  Carlotta Perucca Orfei; Angelo Boffa; Yosef Sourugeon; Lior Laver; Jérémy Magalon; Mikel Sánchez; Thomas Tischer; Giuseppe Filardo; Laura de Girolamo
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2022-09-14       Impact factor: 4.114

Review 6.  Mesenchymal stem cells in knee osteoarthritis treatment: A systematic review and meta-analysis.

Authors:  Yancheng Song; Junhui Zhang; Hualiang Xu; Zhujian Lin; Hong Chang; Wei Liu; Ling Kong
Journal:  J Orthop Translat       Date:  2020-04-27       Impact factor: 5.191

7.  In Vivo Tracking of Human Adipose-derived Mesenchymal Stem Cells in a Rat Knee Osteoarthritis Model with Fluorescent Lipophilic Membrane Dye.

Authors:  Meng Li; Ming Hao; Dong Jiang; Yanxi Chen; Wen Wang
Journal:  J Vis Exp       Date:  2017-10-08       Impact factor: 1.355

8.  The use of allogenic adipose-derived stem cells in combination with platelet-rich fibrin for the treatment of cartilage defects in rabbit ear.

Authors:  Fangfang Xu; Yong Yang; Tao Yang; Taiqiang Dai; Xiaoxi Shao; Haiyan Xu; Ran An; Yanpu Liu; Bin Liu
Journal:  Am J Transl Res       Date:  2018-06-15       Impact factor: 4.060

9.  Osteogenic Stimulation of Human Adipose-Derived Mesenchymal Stem Cells Using a Fungal Metabolite That Suppresses the Polycomb Group Protein EZH2.

Authors:  Rebekah M Samsonraj; Amel Dudakovic; Bushra Manzar; Buer Sen; Allan B Dietz; Simon M Cool; Janet Rubin; Andre J van Wijnen
Journal:  Stem Cells Transl Med       Date:  2017-12-27       Impact factor: 6.940

10.  Efficacy of Platelet-Rich Plasma Containing Xenogenic Adipose Tissue-Derived Stromal Cells on Restoring Intervertebral Disc Degeneration: A Preclinical Study in a Rabbit Model.

Authors:  Chao Ma; Ran Wang; Dingliang Zhao; Naikun Wang; Ying Han; Shichong Wang; Tianyun Gao; Bin Wang; Lijuan Lu
Journal:  Pain Res Manag       Date:  2019-04-16       Impact factor: 3.037
  10 in total

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