Literature DB >> 28296862

A Short Study Report on Bone Marrow Aspirate Concentrate Cell Therapy in Ten South Asian Indian Patients with Autism.

Himanshu Bansal1,2, Poonam Verma2, Anupama Agrawal1,2, Jerry Leon3, I Birgitta Sundell4, Prasad S Koka5.   

Abstract

Autism is a neural disorder presenting in the early developmental period, usually in the first 2 years of life. It is characterized by persistent deficits in social communication and social interaction, restricted and repetitive patterns of behavior, interests, or activities, and causes clinically significant impairment in social, occupational, or other important areas of functioning. Cellular therapy is an advanced approach to treat disorders where current therapies do not offer a cure or efficient symptom relief. Herein we present the data of ten autistic patients who were enrolled in this study utilizing stem cells. All patients were scored on ISAA and WeeFIM scales before and at 3, 6, 12 or 24 months following the injection of stem cells. The ISAA scores of the patients improved with the injection, and no adverse effects were noted. We report promising results in this small pilot study using autologous Bone Marrow Aspirate Concentrate (BMAC) injected intrathecally into these ten enrolled autistic patients.

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Mesh:

Year:  2016        PMID: 28296862

Source DB:  PubMed          Journal:  J Stem Cells        ISSN: 1556-8539


  4 in total

Review 1.  Stem Cell Therapy in the Treatment of Patients With Autism Spectrum Disorder: a Systematic Review and Meta-analysis.

Authors:  Laura Villarreal-Martínez; Gerardo González-Martínez; Melissa Sáenz-Flores; Andrea Judith Bautista-Gómez; Adrián González-Martínez; Miguel Ortiz-Castillo; David Alejandro Robles-Sáenz; Elizabeth Garza-López
Journal:  Stem Cell Rev Rep       Date:  2021-09-13       Impact factor: 5.739

2.  Safety and Feasibility of Repeated Intrathecal Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells in Patients with Neurological Diseases.

Authors:  Kuang Pan; Lingna Deng; Peiying Chen; Qingxia Peng; Jingrui Pan; Yanfeng Wu; Yidong Wang
Journal:  Stem Cells Int       Date:  2019-07-25       Impact factor: 5.443

Review 3.  Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders.

Authors:  Qiang Liu; Mo-Xian Chen; Lin Sun; Chloe U Wallis; Jian-Song Zhou; Li-Juan Ao; Qi Li; Pak C Sham
Journal:  World J Stem Cells       Date:  2019-02-26       Impact factor: 5.326

4.  Outcomes of bone marrow mononuclear cell transplantation combined with interventional education for autism spectrum disorder.

Authors:  Liem Nguyen Thanh; Hoang-Phuong Nguyen; Minh Duy Ngo; Viet Anh Bui; Phuong T M Dam; Hoa Thi Phuong Bui; Doan Van Ngo; Kien Trung Tran; Tung Thi Thanh Dang; Binh Duc Duong; Phuong Anh Thi Nguyen; Nicholas Forsyth; Michael Heke
Journal:  Stem Cells Transl Med       Date:  2020-09-09       Impact factor: 6.940

  4 in total

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