Maru Barrera1,2, Eshetu G Atenafu3, Fiona Schulte4,5, Ute Bartels2, Lillian Sung2, Laura Janzen1,2, Joanna Chung6,7, Danielle Cataudella8,9, Kelly Hancock1,2, Amani Saleh1,2, Douglas Strother5, Dina McConnell6,7, Andrea Downie8,9, Juliette Hukin7, Shayna Zelcer9. 1. Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada. 2. Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada. 3. Department of Biostatistics, University Health Network, Toronto, Ontario, Canada. 4. Department of Psychology, Alberta Children's Hospital, Calgary, Alberta, Canada. 5. Division of Hematology/Oncology, Alberta Children's Hospital, Calgary, Alberta, Canada. 6. Department of Psychology, BC Children's Hospital, Vancouver, British Columbia, Canada. 7. Division of Hematology/Oncology, BC Children's Hospital, Vancouver, British Columbia, Canada. 8. Department of Psychology, London Health Sciences Centre, London, Ontario, Canada. 9. Division of Hematology/Oncology, London Health Sciences Centre, London, Ontario, Canada.
Abstract
INTRODUCTION: To describe the quality of life (QOL) of pediatric brain tumor survivors (PBTSs) prospectively and to identify potential medical, personal and family contextual factors associated with QOL. METHODS: Ninety-one PBTSs (8-16 years) who were off treatment and attending a regular classroom participated. Self- and caregiver-proxy-reported on QOL at baseline, 2 and 8 months. At baseline, cognitive, executive function, attention and memory, medical and demographics information were attained. RESULTS: Significant improvements over time in PBTS's emotional QOL were self- and proxy-reported (P < 0.01) and global QOL proxy-reported (P = 0.04). Receiving cranial irradiation therapy (CIT) and poor behavioral regulation predicted poor global QOL scores reported by both informants (P < 0.017). Poor behavioral regulation also predicted poor self-reported school functioning, and poor proxy-reported emotional and social QOL (P < 0.037). Boys reported better emotional QOL (P = 0.029), and PBTSs over 11 years old were reported to have better emotion and school-related QOL. Finally, being non-White and having low income predicted poor self-reported global and emotional QOL (P = 0.041). CONCLUSIONS: Receiving CIT, having poor behavioral regulation, being a female, under 11 years old and coming from low-income, non-White families place PBTSs at risk for poor QOL.
INTRODUCTION: To describe the quality of life (QOL) of pediatric brain tumor survivors (PBTSs) prospectively and to identify potential medical, personal and family contextual factors associated with QOL. METHODS: Ninety-one PBTSs (8-16 years) who were off treatment and attending a regular classroom participated. Self- and caregiver-proxy-reported on QOL at baseline, 2 and 8 months. At baseline, cognitive, executive function, attention and memory, medical and demographics information were attained. RESULTS: Significant improvements over time in PBTS's emotional QOL were self- and proxy-reported (P < 0.01) and global QOL proxy-reported (P = 0.04). Receiving cranial irradiation therapy (CIT) and poor behavioral regulation predicted poor global QOL scores reported by both informants (P < 0.017). Poor behavioral regulation also predicted poor self-reported school functioning, and poor proxy-reported emotional and social QOL (P < 0.037). Boys reported better emotional QOL (P = 0.029), and PBTSs over 11 years old were reported to have better emotion and school-related QOL. Finally, being non-White and having low income predicted poor self-reported global and emotional QOL (P = 0.041). CONCLUSIONS: Receiving CIT, having poor behavioral regulation, being a female, under 11 years old and coming from low-income, non-White families place PBTSs at risk for poor QOL.
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