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Literature DB >> 28296010

Overview of iron metabolism in health and disease.

Abstract

Iron is an essential element for numerous fundamental biologic processes, but excess iron is toxic. Abnormalities in systemic iron balance are common in patients with chronic kidney disease and iron administration is a mainstay of anemia management in many patients. This review provides an overview of the essential role of iron in biology, the regulation of systemic and cellular iron homeostasis, how imbalances in iron homeostasis contribute to disease, and the implications for chronic kidney disease patients.

Entities: Chemical Disease Gene Mutation Species

Keywords: Iron metabolism; anemia; chronic kidney disease; iron deficiency; iron overload

Mesh：

Substances：
Iron

Year: 2017 PMID： 28296010 PMCID： PMC5977983 DOI： 10.1111/hdi.12542

Source DB: PubMed Journal: Hemodial Int ISSN： 1492-7535 Impact factor: 1.812

144 in total

1. KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease.

Authors:
Journal: Am J Kidney Dis Date: 2006-05 Impact factor: 8.860

2. Hepcidin Mitigates Renal Ischemia-Reperfusion Injury by Modulating Systemic Iron Homeostasis.

Authors: Yogesh Scindia; Paromita Dey; Abhinav Thirunagari; Huang Liping; Diane L Rosin; Matteo Floris; Mark D Okusa; Sundararaman Swaminathan
Journal: J Am Soc Nephrol Date: 2015-03-18 Impact factor: 10.121

3. Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload.

Authors: Martha P Mims; Yongli Guan; Dagmar Pospisilova; Monika Priwitzerova; Karel Indrak; Prem Ponka; Vladimir Divoky; Josef T Prchal
Journal: Blood Date: 2004-09-30 Impact factor: 22.113

Review 4. Role of the hypoxia inducible factors HIF in iron metabolism.

Authors: Carole Peyssonnaux; Victor Nizet; Randall S Johnson
Journal: Cell Cycle Date: 2008-01-01 Impact factor: 4.534

5. Dietary iron intake and risk of coronary disease among men.

Authors: A Ascherio; W C Willett; E B Rimm; E L Giovannucci; M J Stampfer
Journal: Circulation Date: 1994-03 Impact factor: 29.690

6. A cytosolic iron chaperone that delivers iron to ferritin.

Authors: Haifeng Shi; Krisztina Z Bencze; Timothy L Stemmler; Caroline C Philpott
Journal: Science Date: 2008-05-30 Impact factor: 47.728

Review 7. Ironing out Ferroportin.

Authors: Hal Drakesmith; Elizabeta Nemeth; Tomas Ganz
Journal: Cell Metab Date: 2015-10-01 Impact factor: 27.287

8. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis.

Authors: Antonella Roetto; George Papanikolaou; Marianna Politou; Federica Alberti; Domenico Girelli; John Christakis; Dimitris Loukopoulos; Clara Camaschella
Journal: Nat Genet Date: 2002-12-09 Impact factor: 38.330

9. Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans.

Authors: Thomas C Darton; Christoph J Blohmke; Eleni Giannoulatou; Claire S Waddington; Claire Jones; Pamela Sturges; Craig Webster; Hal Drakesmith; Andrew J Pollard; Andrew E Armitage
Journal: PLoS Negl Trop Dis Date: 2015-09-22

10. β-Amyloid precursor protein does not possess ferroxidase activity but does stabilize the cell surface ferrous iron exporter ferroportin.

Authors: Bruce X Wong; Andrew Tsatsanis; Linh Q Lim; Paul A Adlard; Ashley I Bush; James A Duce
Journal: PLoS One Date: 2014-12-02 Impact factor: 3.240

81 in total

Review 1. Liver iron sensing and body iron homeostasis.

Authors: Chia-Yu Wang; Jodie L Babitt
Journal: Blood Date: 2018-11-06 Impact factor: 22.113

2. Emerging Role for Ferroptosis in Infectious Diseases.

Authors: Eduardo Pinheiro Amaral; Sivaranjani Namasivayam
Journal: Adv Exp Med Biol Date: 2021 Impact factor: 2.622

Review 3. Crosstalk between fibroblast growth factor 23, iron, erythropoietin, and inflammation in kidney disease.

Authors: Jodie L Babitt; Despina Sitara
Journal: Curr Opin Nephrol Hypertens Date: 2019-07 Impact factor: 2.894

4. TfR1 Extensively Regulates the Expression of Genes Associated with Ion Transport and Immunity.

Authors: Nan Huang; Lei-Lei Zhan; Yi Cheng; Xiao-Long Wang; Ya-Xun Wei; Qi Wang; Wen-Jing Li
Journal: Curr Med Sci Date: 2020-07-17

5. Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6.

Authors: Susanna Canali; Chia-Yu Wang; Kimberly B Zumbrennen-Bullough; Abraham Bayer; Jodie L Babitt
Journal: Am J Hematol Date: 2017-09-25 Impact factor: 10.047

6. Iron, erythropoietin, and inflammation regulate hepcidin in Bmp2-deficient mice, but serum iron fails to induce hepcidin in Bmp6-deficient mice.

Authors: Chia-Yu Wang; Susanna Canali; Abraham Bayer; Som Dev; Aneesh Agarwal; Jodie L Babitt
Journal: Am J Hematol Date: 2018-12-10 Impact factor: 10.047

Review 7. The role of hepcidin and iron homeostasis in atherosclerosis.

Authors: Florian Wunderer; Lisa Traeger; Haakon H Sigurslid; Patrick Meybohm; Donald B Bloch; Rajeev Malhotra
Journal: Pharmacol Res Date: 2020-01-25 Impact factor: 7.658

8. Copper supplementation reverses dietary iron overload-induced pathologies in mice.

Authors: Tao Wang; Ping Xiang; Jung-Heun Ha; Xiaoyu Wang; Caglar Doguer; Shireen R L Flores; Yujian James Kang; James F Collins
Journal: J Nutr Biochem Date: 2018-06-04 Impact factor: 6.048

Review 9. Ethnic Differences in Iron Status.

Authors: Wanhui Kang; Alexa Barad; Andrew G Clark; Yiqin Wang; Xu Lin; Zhenglong Gu; Kimberly O O'Brien
Journal: Adv Nutr Date: 2021-10-01 Impact factor: 8.701

Review 10. [Progress on epigenetic regulation of iron homeostasis].

Authors: Lingyan Duan; Xiangju Yin; Hong'en Meng; Xuexian Fang; Junxia Min; Fudi Wang
Journal: Zhejiang Da Xue Xue Bao Yi Xue Ban Date: 2020-05-25