Yuchi Liu1,2, Yifan Zhang1,2, Chunying Wu2,3, Junqing Zhu2,3, Charlie Wang1,2, Nicholas Tomko4, Mikhail D Linetsky4, Robert G Salomon4, Ciro Ramos-Estebanez5, Yanming Wang2,3, Xin Yu1,2,3,6. 1. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA. 2. Case Center for Imaging Research, Case Western Reserve University, Cleveland, Ohio, USA. 3. Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA. 4. Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, USA. 5. Department of Neurology, Case Western Reserve University, Cleveland, Ohio, USA. 6. Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, USA.
Abstract
PURPOSE: The current study aimed to develop a three-dimensional (3D) dynamic oxygen-17 (17 O) MR imaging method with high temporal and spatial resolution to delineate the kinetics of 17 O water uptake and washout in the brains of mice with glioblastoma (GBM). METHODS: A 3D imaging method with a stack-of-stars golden-ratio-based radial sampling scheme was employed to acquire 17 O signal in vivo. A k-space-weighted image reconstruction method was used to improve the temporal resolution while preserving spatial resolution. Simulation studies were performed to validate the method. Using this method, the kinetics of 17 O water uptake and washout in the brains of mice with GBM were delineated after an intravenous bolus injection of 17 O water. RESULTS: The proposed 17 O imaging method achieved an effective temporal resolution of 7.56 s with a nominal voxel size of 5.625 μL in the mouse brain at 9.4 T. Reduced uptake and prolonged washout of 17 O water were observed in tumor tissue, suggesting compromised cerebral perfusion. CONCLUSION: This study demonstrated a promising dynamic 17 O imaging approach that can delineate 17 O water kinetics in vivo with high temporal and spatial resolution. It can also be used to image cerebral oxygen consumption rate in oxygen-17 inhalation studies. Magn Reson Med 79:256-263, 2018.
PURPOSE: The current study aimed to develop a three-dimensional (3D) dynamic oxygen-17 (17 O) MR imaging method with high temporal and spatial resolution to delineate the kinetics of 17 O water uptake and washout in the brains of mice with glioblastoma (GBM). METHODS: A 3D imaging method with a stack-of-stars golden-ratio-based radial sampling scheme was employed to acquire 17 O signal in vivo. A k-space-weighted image reconstruction method was used to improve the temporal resolution while preserving spatial resolution. Simulation studies were performed to validate the method. Using this method, the kinetics of 17 O water uptake and washout in the brains of mice with GBM were delineated after an intravenous bolus injection of 17 O water. RESULTS: The proposed 17 O imaging method achieved an effective temporal resolution of 7.56 s with a nominal voxel size of 5.625 μL in the mouse brain at 9.4 T. Reduced uptake and prolonged washout of 17 O water were observed in tumor tissue, suggesting compromised cerebral perfusion. CONCLUSION: This study demonstrated a promising dynamic 17 O imaging approach that can delineate 17 O water kinetics in vivo with high temporal and spatial resolution. It can also be used to image cerebral oxygen consumption rate in oxygen-17 inhalation studies. Magn Reson Med 79:256-263, 2018.
Authors: Li Feng; Robert Grimm; Kai Tobias Block; Hersh Chandarana; Sungheon Kim; Jian Xu; Leon Axel; Daniel K Sodickson; Ricardo Otazo Journal: Magn Reson Med Date: 2013-10-18 Impact factor: 4.668
Authors: Ke Zhang; Hans Herzog; Jörg Mauler; Christian Filss; Thomas W Okell; Elena Rota Kops; Lutz Tellmann; Thomas Fischer; Burkhard Brocke; Walter Sturm; Heinz H Coenen; N Jon Shah Journal: J Cereb Blood Flow Metab Date: 2014-05-21 Impact factor: 6.200