Literature DB >> 28295178

Granulocyte transfusions in the management of invasive fungal infections.

Kamille A West1, Juan Gea-Banacloche2, David Stroncek1, Sameer S Kadri3.   

Abstract

Granulocyte transfusions have a long history of being used in patients with neutropenia or neutrophil dysfunction to prevent and treat invasive fungal infections. However, there are limited and conflicting data concerning its clinical effectiveness, considerable variations in current granulocyte transfusion practices, and uncertainties about its benefit as an adjunct to modern antifungal therapy. In this review, we provide an overview on granulocyte transfusions and summarize the evidence on their role in the prevention and treatment of invasive fungal infections.
© 2017 John Wiley & Sons Ltd.

Entities:  

Keywords:  fungal infection; granulocytes; leukapheresis; neutropenia; transfusions

Mesh：

Year:  2017        PMID： 28295178      PMCID： PMC5403628          DOI： 10.1111/bjh.14597

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  136 in total

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3.  Single-donor granulocyte transfusions for improving the outcome of high-risk pediatric patients with known bacterial and fungal infections undergoing stem cell transplantation: a 10-year single-center experience.

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7.  Leucocyte transfusions from rhG-CSF or prednisolone stimulated donors for treatment of severe infections in immunocompromised neutropenic patients.

Authors:  C Peters; M Minkov; S Matthes-Martin; U Pötschger; V Witt; G Mann; P Höcker; N Worel; J Stary; T Klingebiel; H Gadner
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