Frank Benedix1, Thomas Krause2, Daniela Adolf3, Stefanie Wolff2, Hans Lippert2, Thomas Manger4, Christine Stroh4. 1. Department of Surgery, University Hospital Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany. frankbenedix@gmx.de. 2. Department of Surgery, University Hospital Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany. 3. StatConsult Magdeburg, Halberstädter Strasse 40a, 39112, Magdeburg, Germany. 4. SRH Municipal Hospital Gera, Straße des Friedens 122, 07548, Gera, Germany.
Abstract
BACKGROUND: Morbid obesity in both adolescents and adults has risen in an alarming rate. Bariatric surgery is playing an increasing role in pediatric surgery. However, current evidence is limited regarding its safety and outcome. METHODS: Since 2005, data from obese patients that undergo bariatric procedures in Germany are prospectively registered. For the current analysis, all adolescent and adult subjects that had undergone laparoscopic sleeve gastrectomy (LSG) from 2005 to 2014 were considered. RESULTS: LSG represents the most common bariatric procedure in Germany with a proportion of 48.1% in adolescent and 48.7% in adult obese in 2014. LSG was performed in 362 adolescent and 15,428 adult subjects. Pre-operative BMI was comparable between the two populations. However, adult obese had more frequently coexisting comorbidities (p < 0.01). Complication rates and mortality (0 vs. 0.2%) did not differ significantly. Adolescents achieved a BMI reduction of 16.8 and 18.0 kg/m2 at 12 and 24 months compared with 15.4 and 16.6 kg/m2 in the adult group. There was a significantly higher BMI reduction in late adolescents (19-21 years) compared with patients ≤18 years at 24 months (19.8 vs. 13.6 kg/m2). Resolution rate of hypertension was significantly higher in adolescents. CONCLUSION: LSG is a safe therapeutic option that can be performed in adolescents without mortality. Late adolescents experienced the highest weight loss; resolution rate of comorbidities was lower in adults. All future efforts should now be focused on the evaluation of the long-term outcomes of LSG in the pediatric population.
BACKGROUND: Morbid obesity in both adolescents and adults has risen in an alarming rate. Bariatric surgery is playing an increasing role in pediatric surgery. However, current evidence is limited regarding its safety and outcome. METHODS: Since 2005, data from obesepatients that undergo bariatric procedures in Germany are prospectively registered. For the current analysis, all adolescent and adult subjects that had undergone laparoscopic sleeve gastrectomy (LSG) from 2005 to 2014 were considered. RESULTS: LSG represents the most common bariatric procedure in Germany with a proportion of 48.1% in adolescent and 48.7% in adult obese in 2014. LSG was performed in 362 adolescent and 15,428 adult subjects. Pre-operative BMI was comparable between the two populations. However, adult obese had more frequently coexisting comorbidities (p < 0.01). Complication rates and mortality (0 vs. 0.2%) did not differ significantly. Adolescents achieved a BMI reduction of 16.8 and 18.0 kg/m2 at 12 and 24 months compared with 15.4 and 16.6 kg/m2 in the adult group. There was a significantly higher BMI reduction in late adolescents (19-21 years) compared with patients ≤18 years at 24 months (19.8 vs. 13.6 kg/m2). Resolution rate of hypertension was significantly higher in adolescents. CONCLUSION: LSG is a safe therapeutic option that can be performed in adolescents without mortality. Late adolescents experienced the highest weight loss; resolution rate of comorbidities was lower in adults. All future efforts should now be focused on the evaluation of the long-term outcomes of LSG in the pediatric population.
Entities:
Keywords:
Adolescents; Adults; German multicenter trial; Obesity; Sleeve gastrectomy
Authors: David Nocca; Marius Nedelcu; Anamaria Nedelcu; Patrick Noel; Phillipe Leger; Mehdi Skalli; Patrick Lefebvre; Yannael Coisel; Caroline Laurent; Frederic Lemaitre; Jean Michel Fabre Journal: Obes Surg Date: 2014-06 Impact factor: 4.129
Authors: Thomas H Inge; Anita P Courcoulas; Todd M Jenkins; Marc P Michalsky; Michael A Helmrath; Mary L Brandt; Carroll M Harmon; Meg H Zeller; Mike K Chen; Stavra A Xanthakos; Mary Horlick; C Ralph Buncher Journal: N Engl J Med Date: 2015-11-06 Impact factor: 91.245
Authors: Thomas H Inge; Meg H Zeller; Todd M Jenkins; Michael Helmrath; Mary L Brandt; Marc P Michalsky; Carroll M Harmon; Anita Courcoulas; Mary Horlick; Stavra A Xanthakos; Larry Dolan; Mark Mitsnefes; Sean J Barnett; Ralph Buncher Journal: JAMA Pediatr Date: 2014-01 Impact factor: 16.193
Authors: Sarah B Ogle; Lindel C Dewberry; Todd M Jenkins; Thomas H Inge; Megan Kelsey; Matias Bruzoni; Janey S A Pratt Journal: Pediatrics Date: 2021-02-01 Impact factor: 7.124