Literature DB >> 2829354

Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6).

G Tosato1, K B Seamon, N D Goldman, P B Sehgal, L T May, G C Washington, K D Jones, S E Pike.   

Abstract

Soluble products of either Epstein-Barr virus (EBV)-infected B cells or activated monocytes promote the proliferation of EBV-infected B cells and permit their growth at low cell densities. This suggests that growth factors are important for B-cell immortalization by EBV. In this study, a monocyte-derived factor that promotes the growth of EBV-infected b cells was purified and identified as interferon-beta 2 (IFN-beta 2), which is also known as 26-kilodalton protein, B-cell differentiation factor (BSF-2), and interleukin-6 (IL-6). The purified protein has a specific activity of approximately 4 X 10(7) units per milligram of protein in assays of B-cell growth. Thus, IFN-beta 2/BSF-2 is a B-cell growth factor that promotes the proliferation of human B cells infected with EBV.

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Year:  1988        PMID： 2829354     DOI： 10.1126/science.2829354

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  78 in total

1.  Identification and characterization of lipopolysaccharide-binding proteins on human peripheral blood cell populations.

Authors:  J L Halling; D R Hamill; M G Lei; D C Morrison
Journal:  Infect Immun       Date:  1992-03       Impact factor: 3.441

2.  Factor(s) required by EBV transformed lymphocytes to grow under limiting dilution conditions.

Authors:  C Negri; R Chiesa; G C Ricotti
Journal:  Cytotechnology       Date:  1991-11       Impact factor: 2.058

3.  The role of lactic acid in autocrine B-cell growth stimulation.

Authors:  S E Pike; S P Markey; C Ijames; K D Jones; G Tosato
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

4.  Interleukin 2-dependent and interleukin 2-independent pathways of regulation of thymocyte function by interleukin 6.

Authors:  J M Le; G Fredrickson; L F Reis; T Diamantstein; T Hirano; T Kishimoto; J Vilcek
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

5.  Requirements for tumor necrosis factor-alpha and interleukin-1 in limb ischemia/reperfusion injury and associated lung injury.

Authors:  A Seekamp; J S Warren; D G Remick; G O Till; P A Ward
Journal:  Am J Pathol       Date:  1993-08       Impact factor: 4.307

6.  A synthetic analog of the 3-deoxy-D-manno-2-octulosonic acid disaccharide moiety of rough-type endotoxins does not bind to mouse peritoneal macrophages and human monocytes.

Authors:  R Girard; T Pedron; P Kosma; R Chaby
Journal:  Infect Immun       Date:  1993-09       Impact factor: 3.441

Review 7.  Epstein-Barr virus, infectious mononucleosis, and posttransplant lymphoproliferative disorders.

Authors:  M A Nalesnik; T E Starzl
Journal:  Transplant Sci       Date:  1994-09

8.  A role for deregulated c-Myc expression in apoptosis of Epstein-Barr virus-immortalized B cells.

Authors:  B W Cherney; K Bhatia; G Tosato
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

9.  Interleukin-6 protects anterior horn neurons from lethal virus-induced injury.

Authors:  Kevin D Pavelko; Charles L Howe; Kristen M Drescher; Jeff D Gamez; Aaron J Johnson; Tao Wei; Richard M Ransohoff; Moses Rodriguez
Journal:  J Neurosci       Date:  2003-01-15       Impact factor: 6.167

10.  Defective production of interleukin-6 in very small premature infants in response to bacterial pathogens.

Authors:  A Yachie; N Takano; K Ohta; T Uehara; S Fujita; T Miyawaki; N Taniguchi
Journal:  Infect Immun       Date:  1992-03       Impact factor: 3.441
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